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Chemicals
Endothelin 1621 CAS 121377671 China Suppliers Factory High Purity ETB Receptor Agonist
Looking for high-purity Endothelin 16-21? As leading China suppliers and a GMP-certified factory, we provide the potent ETB receptor agonist CAS 121377-67-1 for cardiovascular and pulmonary research, ensuring 98% purity and rapid global delivery.
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
Product information from the supplier.
Endothelin (16-21), identified by CAS NO. 121377-67-1, is a high-purity synthetic hexapeptide specifically engineered as a potent and selective ETB receptor agonist. By selectively binding to ETB receptors with high affinity, this research-grade peptide triggers Gq-protein coupled signaling, leading to a rapid increase in intracellular calcium concentration, which effectively induces smooth muscle contraction. This makes it an indispensable tool for vascular biologists and pharmacologists studying the nuances of cardiovascular and respiratory physiology.
Designed for rigorous in vitro and ex vivo research, Endothelin (16-21) provides critical insights into ETB receptor-mediated pathology. It is widely utilized in the investigation of pulmonary hypertension, airway hyperreactivity associated with asthma, and systemic hypertension. With a purity level of ≥98% and strict adherence to GMP-compliant production systems, our peptide ensures reproducible results for screening novel receptor antagonists and establishing proof-of-concept for targeted therapeutic strategies in cardiorespiratory diseases.
Detailed Parameters
| Product Name | Endothelin (16-21) | CAS NO. | 121377-67-1 |
|---|---|---|---|
| Appearance | White to off-white lyophilized powder | Molecular Formula | C₃₉H₅₇N₉O₉ |
| Molecular Weight | 804.0g/mol | Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in 1M acetic acid, DMSO, or deionized water | Endotoxin | ≤1 EU/mg |
| Storage Conditions | Store at -20°C, protected from light/moisture | MOQ | 1g |
Key Advantages
Ultra-High Purity
Guaranteed purity of ≥98% via RP-HPLC, ensuring precise and reliable experimental outcomes for sensitive research.
Selective Agonism
Exhibits high affinity for ETB receptors (EC50 ~228 nM) with negligible activity at ETA receptors.
GMP Compliance
Produced in GMP-compliant systems with standardized quality control from raw materials to final packaging.
Full Documentation
Each batch is accompanied by a COA, HPLC purity report, and mass spectrometry (MS) chromatograms.
Rapid Logistics
Specialized global shipping via DHL, FedEx, and UPS to ensure product stability and rapid delivery.
US Stock Availability
Strategic stock location in USA allows for minimized transit times and faster access for North American labs.
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Management Platforms
Batch Traceability
Comprehensive tracking from synthesis to delivery for every single batch produced.
Quality Validation
Professional laboratory testing using HPLC and MS for uncompromising purity validation.
Regulatory Compliance
Adherence to international trade standards and pharmaceutical grade production protocols.
Cold Chain Control
Strict temperature monitoring at -20°C to prevent degradation of sensitive peptides.
Custom Packaging
Tailored packaging solutions to meet specific stability and laboratory storage requirements.
R&D Collaboration
Partnerships with top universities to scale production from gram to ton levels.
Investment Return Comparison
| Research Metric | Standard Grade Peptide | GlobalTech Premium Peptide |
|---|---|---|
| Purity Level | < 95% | ≥ 98% (RP-HPLC) |
| Receptor Selectivity | Variable/Mixed | High ETB Specificity |
| Documentation | Basic COA | COA, HPLC, MS Reports |
| Stability | Standard Storage | Optimized Lyophilization |
| Lead Time | Long Lead Times | Rapid US/Global Dispatch |
Frequently Asked Questions
Q: What is the primary application of Endothelin (16-21) in pharmaceutical research?
It is primarily used as a selective probe to study ETB receptor-mediated physiology, specifically in investigating pulmonary hypertension, asthma, and smooth muscle contractility.
Q: How should Endothelin (16-21) be stored to maintain its biological activity?
The product should be stored at -20°C and kept protected from light and moisture to ensure long-term stability and potency.
Q: Can this peptide be dissolved in water?
Yes, Endothelin (16-21) is soluble in deionized water, 1M acetic acid, and DMSO.
Q: Is Endothelin (16-21) suitable for clinical use in humans?
No, this product is intended strictly for in vitro and ex vivo research applications and is not for clinical or diagnostic use.
Q: What quality certifications do your manufacturing partners hold?
Our partners utilize GMP-compliant production systems and often hold DMF and FDA certifications to ensure the highest industry standards.
Q: What is the minimum order quantity (MOQ) for this chemical?
The minimum order quantity for Endothelin (16-21) is 1g, suitable for both small-scale laboratory tests and larger research projects.
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