NepsilonCarboxymethyllysine CML CAS 5746043 China Factory Suppliers

Looking for high-purity N-epsilon-Carboxymethyllysine (CML) CAS 5746-04-3? Our China factory provides premium research-grade CML as a critical AGE standard for oxidative stress and protein glycation studies. Trust the leading China suppliers for HPLC-grade purity and GMP-compliant biochemical reagents.

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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About this product

Product information from the supplier.

Nε-(Carboxymethyl)lysine (CML), CAS NO.5746-04-3, is a premier research-grade chemical serving as a critical marker for Advanced Glycation End-products (AGEs). As a primary byproduct of the Maillard reaction and protein glycation, CML is indispensable for scientific professionals studying oxidative stress, protein modification, and the pathological mechanisms of chronic hyperglycemia.

Engineered for high precision, our CML is specifically designed for in vitro research and analytical applications. It provides a reliable molecular basis for modeling diabetic complications, cardiovascular diseases, and neurodegenerative conditions, while serving as a gold-standard calibration tool for high-performance liquid chromatography (HPLC) and immunoassays in pharmaceutical and food science labs.

Detailed Parameters

Product Name	Nε-(Carboxymethyl)lysine	CAS NO.	5746-04-3
Molecular Formula	C8H16N2O4	Molecular Weight	204.22 g/mol
Purity (RP-HPLC)	≥98%	Appearance	White to off-white powder
Solubility	Water, Methanol, DMSO	Endotoxin	< 1.0 EU/mg
Storage Conditions	-20°C, Dry and Dark	Stock Location	USA Warehouse

Key Advantages

Ultra-High Purity

Achieving ≥98% purity via RP-HPLC to ensure precise and reproducible experimental results in sensitive biochemical assays.

Rapid Global Delivery

Strategically stocked in the USA and shipped via DHL/FedEx/UPS to minimize transit time and maintain product stability.

GMP Compliant

Produced under strict GMP-compliant systems with standardized quality control from synthesis to final packaging.

RAGE Signaling Focus

Specifically optimized for activating the Receptor for Advanced Glycation End products (RAGE) in disease modeling.

Full Documentation

Each batch is accompanied by a comprehensive COA, HPLC purity reports, and MS chromatograms for full transparency.

Analytical Standard

Ideal as a calibration standard for the accurate quantification of CML adducts in plasma and tissue homogenates.

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Management Platforms

Batch Traceability

Comprehensive tracking from raw material procurement to final delivery ensuring absolute consistency.

Quality Validation

Rigorous laboratory testing including MS and HPLC to validate purity and biological activity.

Cold Chain Logistics

Specialized packaging solutions to prevent freeze-thaw cycles and maintain the -20°C stability requirement.

Regulatory Compliance

Strict adherence to international trade standards and pharmaceutical-grade chemical export regulations.

Flexible Scale-up

Capabilities ranging from milligram-level research samples to ton-level industrial API supply.

Academic Collaboration

Close partnerships with renowned university laboratories to stay at the forefront of peptide research.

Investment Return Comparison

Research Metric	Standard Reagents	Our High-Purity CML
Experimental Precision	Variable/Low	Ultra-High (≥98%)
RAGE Activation Rate	Inconsistent	Highly Reliable
Batch-to-Batch Stability	Moderate	Excellent (Traceable)
Setup Time/Calibration	Long/Frequent	Rapid/Standardized
Risk of Contamination	Medium	Minimal (Endotoxin Controlled)

Frequently Asked Questions

Q: What are the primary applications of Nε-(Carboxymethyl)lysine in pharmaceutical research?

CML is primarily used as a biochemical tool to study Advanced Glycation End-products (AGEs). It is essential for researching diabetic complications, vascular calcification, and the activation of RAGE signaling pathways in neurodegenerative diseases.

Q: How should I store CML to maintain its biological activity?

CML should be stored at -20°C in a dry, dark environment. It is critical to avoid repeated freeze-thaw cycles to prevent degradation and ensure the stability of the peptide structure.

Q: Is this product suitable for therapeutic use in humans?

No, this product is indicated strictly for in vitro research and analytical applications. It is intended for use by scientific professionals in laboratory settings and is not for therapeutic or clinical use.

Q: What quality documentation is provided with each shipment?

Every batch comes with a complete documentation package, including a Certificate of Analysis (COA), an RP-HPLC purity report, and mass spectrometry (MS) chromatograms to verify identity and purity.

Q: How does CML affect cellular signaling pathways?

CML binds to the RAGE receptor, triggering a signaling cascade that includes the MAPK (ERK1/2) and NF-κB routes. This leads to the production of reactive oxygen species (ROS) and pro-inflammatory cytokines.

Q: Can this product be used for food science quality control?

Yes, it serves as a vital calibration standard for food technologists to assess the impact of thermal processing (Maillard reaction) and storage on the nutritional quality and glycation levels of food extracts.