CRAMP mouse CAS 376364362 High Purity Peptide China Suppliers Factory

High-purity CRAMP mouse (CAS 376364-36-2) supplied by a leading China factory. As the murine ortholog to human LL-37, this research-grade peptide is essential for immunological and microbiological studies. Contact professional suppliers for premium lyophilized powder with 99% purity.

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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About this product

Product information from the supplier.

CRAMP (mouse), identified by CAS NO. 376364-36-2, is a high-purity cationic antimicrobial peptide critical for advanced immunological and microbiological research. As a murine analog to human LL-37, this lyophilized powder is engineered to provide potent bactericidal activity against a wide spectrum of Gram-positive and Gram-negative pathogens, making it an indispensable reagent for studying innate immunity and mucosal homeostasis.

Beyond its direct antimicrobial properties, CRAMP operates through a sophisticated dual-action mechanism involving microbial membrane disruption and the modulation of host immune responses via Fpr2 receptors. From investigating multidrug-resistant bacterial biofilms to exploring tissue repair and intestinal inflammation in preclinical murine models, this research-grade peptide ensures precision and reproducibility in complex laboratory assays.

Detailed Parameters

Product Name	CRAMP (mouse)	CAS NO.	376364-36-2
Molecular Formula	C178H302N50O46	Molecular Weight	3878.67 g/mol
Purity (RP-HPLC)	≥99.0%	Appearance	White to off-white powder
Endotoxin	≤0.5 EU/mg	Solubility	Water, dilute acetic acid, PBS
Storage	-20°C, dry and dark	MOQ	1 kit

Key Advantages

Broad-Spectrum Potency

Exhibits rapid bactericidal activity against E. coli, P. aeruginosa, and S. aureus without fostering resistance.

Rapid Membrane Lysis

Utilizes electrostatic attraction to create toroidal pores, leading to immediate osmotic lysis of target cells.

Immune Modulation

Triggers MAPK pathways and recruits neutrophils/macrophages via Fpr2 receptors for enhanced healing.

Mucosal Protection

Proven efficacy in protecting colon crypts and suppressing DSS-induced ulcerative colitis in murine systems.

Ultra-High Purity

≥99.0% purity verified by RP-HPLC and MS, ensuring consistent results in sensitive analytical assays.

Full Traceability

Every batch is accompanied by a COA and HPLC report for complete regulatory and research transparency.

Product Gallery

Management Platforms

GMP Production

All synthesis partners adhere to strict GMP-compliant systems for pharmaceutical grade quality.

Rigorous QC

Standardized quality control covering raw materials, purification, and stability testing.

Batch Validation

Comprehensive documentation including COA, MS chromatograms, and 3rd party reports.

Cold-Chain Logistics

Specialized packaging to maintain -20°C stability during international air freight.

Scalable Supply

Capabilities ranging from gram-level research quantities to ton-level industrial production.

Global Compliance

Strict adherence to international trade standards and FDA/DMF certified manufacturing sources.

Investment Return Comparison

Feature Metric	Standard Peptides	GlobalTech CRAMP
Purity Level	< 95%	≥ 99.0% (HPLC)
Endotoxin Control	Unspecified	≤ 0.5 EU/mg
Bio-Activity	Variable	Potent/Validated
Documentation	Basic COA	COA + MS + HPLC
Delivery Speed	Standard Freight	Express Air Freight

Frequently Asked Questions

Q: What is the primary application of CRAMP (mouse) in pharmaceutical research?

It is primarily used as a reagent in in vitro laboratory research and preclinical animal models to study innate immunity, antimicrobial potency against drug-resistant bacteria, and the regulation of gut mucosal homeostasis.

Q: How does CRAMP differ from human LL-37?

CRAMP is the murine ortholog of human LL-37. While they share similar amphipathic alpha-helical structures and antimicrobial functions, CRAMP is specifically optimized for use in mouse-based biological systems.

Q: What are the recommended storage conditions for this peptide?

It should be stored at -20°C in a dry, dark, and well-sealed container. To maintain biological activity, avoid repeated freeze-thaw cycles.

Q: Is CRAMP (mouse) suitable for clinical use in humans?

No, this product is strictly designated for research use only. It is not a clinical therapeutic agent and should not be administered to humans.

Q: How is the purity of the peptide verified?

Purity is verified using Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) and Mass Spectrometry (MS) to ensure it meets the ≥99.0% standard.

Q: Can GlobalTech provide custom packaging for bulk orders?

Yes, we can customize packaging according to specific customer needs to ensure product stability and compliance with local transportation regulations.