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Chemicals
2-Acetylacteoside CAS NO.94492-24-7
<p><strong>2-Acetylacteoside</strong> (also known as 2′-O-acetylacteoside or isoacteoside acetate) is a high-purity acylated phenylethanoid glycoside (PhGs) naturally isolated from medicinal plants such as <em>Cistanche deserticola</em>and <em>Boschniakia rossica</em>, supplied as a pale yellow to off-white amorphous powder for pharmacological research and natural product standardization. This bioactive compound fea…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification | |
|---|---|---|
| Product Name | 2-Acetylacteoside | |
| CAS NO. | 94492-24-7 | |
| Appearance | White to off-white amorphous powder | |
| Molecular Formula | C31H38O16 | |
| Molecular Weight | 666.63 g/mol | |
| Purity (RP-HPLC) | ≥ 98.0% | |
| Solubility | Soluble in DMSO, Methanol, Ethanol; slightly soluble in Water | |
| Endotoxin | < 10 EU/mg | |
| Biological Activity |
| |
| Storage Conditions | Store at -20°C, protected from light and moisture. Keep container tightly sealed. | |
| Stock Location | Stock in USA | |
| MOQ | 1g |
1.MECHANISM OF ACTION
2-Acetylacteoside exerts its primary biological effects by activating the Nrf2/ARE (Antioxidant Response Element) signaling pathway, which upregulates endogenous antioxidant enzymes including heme oxygenase-1 (HO-1), superoxide dismutase (SOD), and glutathione peroxidase to neutralize reactive oxygen species (ROS) and prevent lipid peroxidation. It also protects neuronal cells from β-amyloid-induced toxicity by inhibiting the mitochondrial apoptotic cascade—suppressing Bax translocation, cytochrome c release, and caspase-3 activation—while preserving mitochondrial membrane potential (ΔΨm). Additionally, the compound modulates cholinergic neurotransmission by mildly inhibiting acetylcholinesterase (AChE) activity and suppresses pro-inflammatory mediator production (TNF-α, IL-1β, NO) via NF-κB pathway inhibition, collectively shifting the cellular environment from a pro-oxidative, pro-apoptotic state to a neuroprotective and metabolically balanced condition.
2.PRODUCT INDICATIONS
2-Acetylacteoside is indicated for non-clinical research applications in neuropharmacology, gerontology, and phytochemistry, where it is utilized to study potential therapeutics for Alzheimer's disease, Parkinson's disease, and cerebral ischemia-reperfusion injury in cellular and animal models. Researchers employ this compound to investigate anti-senescence effects, sperm motility enhancement (as observed in certain Cistanche glycosides), and the structure-activity relationships of acetylated vs. non-acetylated phenylethanoid glycosides in antioxidant assays. Furthermore, it serves as a primary pharmaceutical reference standard for analytical chemists developing chromatographic methods to quantify minor acylated phenylethanoids in Cistancheextracts, catering to professionals in traditional Chinese medicine (TCM) quality control, anti-aging cosmeceutical R&D, and preclinical neuroprotective drug discovery.
3.CLINICAL EFFICACY OF PRODUCT
2-Acetylacteoside has demonstrated significant efficacy in preclinical neuroprotection models, where it dose-dependently improved PC12 cell viability after H₂O₂-induced oxidative insult and attenuated Aβ₁₋₄₂-triggered apoptosis, with EC₅₀ values often superior to or comparable with verbascoside due to enhanced lipophilicity from acetylation. In in vivo studies using scopolamine-induced memory deficit mice, related Cistanche phenylethanoids (including acetyl-substituted acteosides) significantly shortened escape latency in Morris water maze tests and restored acetylcholinesterase balance in hippocampal tissue. Additionally, the compound exhibits notable DPPH and ABTS radical-scavenging capacity (IC₅₀ in low μg/mL range), effectively preserves SOD and GSH levels in stressed cells, and shows inhibitory effects on AChE (IC₅₀ ~50–80 μM in some PhGs of the same class), establishing its robust potential as a neuroprotective and cognition-enhancing lead for ongoing pharmacological validation.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
HotTags:2-Acetylacteoside, 2′-O-Acetylacteoside, Phenylethanoid Glycoside, PhGs, Cistanche Deserticola, Rou Cong Rong, Neuroprotective, Antioxidant, Nrf2 Activator, AChE Inhibitor, Anti-aging, Natural Product, Research Standard, Verbascside Derivative, Herbal Extract Marker
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