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Chemicals
Glycoursodeoxycholic acid CAS NO.64480-66-6
<p><strong>Glycoursodeoxycholic Acid (GUDCA)</strong> is a high-purity glycine-conjugated secondary bile acid, the major amidated metabolite of ursodeoxycholic acid (UDCA), isolated as a white to off-white crystalline powder for research use only. This endogenous metabolite is supplied as a reference standard for studying enterohepatic circulation, bile acid pool composition, and the metabolic signaling roles of con…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Glycoursodeoxycholic acid (GUDCA) |
| CAS NO. | 64480-66-6 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C26H43NO5 |
| Molecular Weight | 449.63 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in DMSO, DMF, Methanol, Ethanol; slightly soluble in aqueous buffer (PBS) |
| Endotoxin | < 10 EU/mg |
| Biological Activity | Glycine-conjugated secondary bile acid (metabolite of UDCA); exhibits cytoprotective, anti-inflammatory and FXR-modulating effects; used in gut microbiota–bile acid metabolism research. |
| Storage Conditions | Store at -20°C, protected from light and moisture. Keep container tightly sealed. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Glycoursodeoxycholic Acid acts as a ligand and partial agonist for the farnesoid X receptor (FXR, NR1H4) and the G-protein coupled bile acid receptor (TGR5/GPBAR1), thereby regulating the transcription of genes involved in bile acid synthesis, conjugation, and hepatic export via the FXR-SHP and FXR-FGF19 axes. It suppresses pro-inflammatory NF-κB signaling and reduces oxidative stress by scavenging reactive oxygen species and preventing mitochondrial cytochrome c oxidase inhibition, while also modulating platelet activation through suppression of diacylglycerol kinase (DGK) activity. Additionally, GUDCA influences gut microbiota composition—particularly enriching Akkermansia muciniphilaand certain Bacteroidesspecies—which in turn alters secondary bile acid pools and systemic metabolic homeostasis.
2.PRODUCT INDICATIONS
Glycoursodeoxycholic Acid is indicated for non-clinical research focused on hepatobiliary physiology, cholestasis models, and metabolic disorder studies including non-alcoholic fatty liver disease (NAFLD), type 2 diabetes, and atherosclerosis in murine models. It is routinely employed by investigators screening FXR/TGR5 agonists, evaluating bile acid-mediated cytoprotection against bilirubin- or toxin-induced neuronal injury, and standardizing LC-MS/MS metabolomics panels for endogenous bile acid profiling. The compound also serves as a critical analytical reference for manufacturers of bile acid assay kits and for quality control labs verifying the composition of conjugated bile acid fractions in biological or pharmaceutical samples.
3.CLINICAL EFFICACY OF PRODUCT
Glycoursodeoxycholic Acid has shown robust bioactivity in preclinical models, significantly attenuating experimental colitis by restoring beneficial gut microbiota and reducing inflammatory cytokine production in dextran sulfate sodium (DSS)-induced mice. In metabolic disease models, oral GUDCA administration improved glucose tolerance, reduced hepatic steatosis, and lowered plasma triglycerides by activating TGR5-driven thermogenesis in adipose tissue and inhibiting FXR-mediated lipogenesis. Furthermore, it demonstrated neuroprotective efficacy by rescuing neurons and astrocytes from unconjugated bilirubin-induced oxidative damage and apoptosis, and exhibited antithrombotic potential by dose-dependently inhibiting platelet aggregation without increasing bleeding time in animal studies, highlighting its multipronged therapeutic relevance in metabolic and vascular research.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
HotTags:Glycoursodeoxycholic Acid, GUDCA, Ursodeoxycholylglycine, Glycine Ursodeoxycholate, Bile Acid Conjugate, Secondary Bile Acid, FXR Agonist, TGR5 Agonist, Endogenous Metabolite, Hepatoprotective, Anti-inflammatory, Neuroprotective, Gut Microbiota Modulator, Research Standard, CAS 64480-66-6
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