Ginsenosi Rg4 CAS NO.126223-28-7
<p>Ginsenoside Rg4 is a unique tetracyclic triterpenoid saponin and a bioactive component found in ginseng, distinguished by its rapid absorption and ability to modulate multiple signaling pathways. It serves as a critical reference standard for pharmacological research, particularly in studies focused on anti-aging, neuroprotection, and immune modulation, making it indispensable for scientists exploring the mechani…
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TECHNICAL SPECIFICATIONS
Item | Specification |
|---|---|
Product Name | Ginsenoside Rg4 |
CAS NO. | 126223-28-7 |
Appearance | White to off-white amorphous powder |
Molecular Formula | C42H70O12 |
Molecular Weight | 767.0 g/mol |
Purity (HPLC) | ≥98% |
Solubility | Soluble in water, methanol, DMSO; insoluble in acetone |
Storage Conditions | Store at 2-8°C, protected from light and humidity |
Grade | Natural Product / Research Grade |
Source | Extracted from Panax ginsengC.A. Meyer (Root/Stem) |
1.Mechanism of Action
Ginsenoside Rg4 exerts its therapeutic effects primarily by interacting with nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways to inhibit inflammatory cytokine production, while also activating adenosine A1 receptors to provide neuroprotective benefits. Its molecular actions include enhancing cellular autophagy, regulating calcium ion homeostasis, and stimulating mitochondrial biogenesis, which collectively contribute to its cardioprotective and anti-apoptotic functions in stressed cellular environments.


2.Product Indications
This compound is specifically indicated for use in preclinical and clinical research aimed at investigating age-related cognitive decline, neurodegenerative disorders such as Alzheimer's disease, cardiovascular protection, and stress-induced immunosuppression. It is an essential tool for researchers in pharmacology, toxicology, and natural product chemistry seeking to validate the efficacy and safety profiles of ginseng-derived compounds in cell cultures, animal models, and human pilot studies.

3.Clinical Efficacy of Product
While primarily a research chemical, emerging clinical data suggest that Ginsenoside Rg4 demonstrates significant efficacy in improving microcirculation, reducing oxidative stress markers, and enhancing cognitive performance in elderly populations and patients with mild cognitive impairment. Its ability to cross the blood-brain barrier and exert localized neuroprotective effects has shown promising results in phase I and II trials, supporting its potential as a therapeutic agent for preventing neurodegeneration and improving quality of life in at-risk demographics.

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