ACTH (18-39) (human) CAS NO.53917-42-3

TECHNICAL SPECIFICATIONS

1.Mechanism of Action

ACTH (18-39) (human) exerts its physiological effects by binding with high affinity to the melanocortin type 2 receptor (MC2R) on adrenal cortical cells, activating adenylate cyclase and increasing intracellular cAMP levels. This signaling cascade triggers cholesterol mobilization, steroidogenic enzyme expression, and ultimately cortisol biosynthesis and secretion. Unlike full-length ACTH, this fragment lacks pro-opiomelanocortin (POMC) N-terminal regions, making it a more specific tool for studying adrenal-specific responses without confounding pituitary or neural effects.

2.Product Indications

This peptide is indicated for use in academic, pharmaceutical, and biotechnology research focused on adrenal physiology, endocrine disorders such as Addison’s disease and Cushing’s syndrome, and drug development targeting HPA axis modulation. It is also valuable for screening compounds that influence cortisol production, evaluating adrenal insufficiency treatments, and studying melanocortin receptor pharmacology. Researchers in neuroendocrinology, immunology, and metabolic disease models will find this fragment particularly useful for dissecting ACTH-specific pathways.

3.Clinical Efficacy of Product

While not intended for direct human therapeutic use, ACTH (18-39) (human) demonstrates robust efficacy in preclinical models for evaluating adrenal responsiveness and steroidogenic capacity. In animal studies, it reliably induces cortisol release and supports investigations into adrenal atrophy, stress-induced hyperglycemia, and anti-inflammatory glucocorticoid effects. Its consistent activity across multiple species enhances translational relevance, making it a trusted reference standard in endocrine research and a critical component in validating novel therapies targeting adrenal or melanocortin pathways.

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

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1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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