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Chemicals
14-Deoxyandrographolide CAS NO.4176-97-0
<p>14-Deoxyandrographolide is a labdane-type diterpene lactone isolated from the medicinal herb <em>Andrographis paniculata</em>, supplied as a high-purity white to off-white powder primarily intended for pharmacological research, natural product chemistry, and the development of standardized botanical reference materials. This bioactive compound serves as a critical tool for scientists investigating the therapeutic…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | 14-Deoxyandrographolide |
| CAS NO. | 4176-97-0 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C20H30O4 |
| Molecular Weight | 334.45 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in DMSO, Methanol, Ethanol, Chloroform; insoluble in water |
| Endotoxin | < 10 EU/mg |
| Biological Activity | Labdane-type diterpenoid lactone with anti-inflammatory, hepatoprotective, antidiabetic, and anticancer (apoptosis inducer) properties; inhibits calcium channels. |
| Storage Conditions | Store at -20°C, protected from light and moisture. Keep container tightly sealed. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
14-Deoxyandrographolide exerts its diverse biological effects by modulating multiple intracellular signaling cascades, most notably through the activation of AMP-activated protein kinase (AMPK) via the cyclic AMP-protein kinase A (cAMP-PKA) pathway, which subsequently regulates lipid metabolism and glucose uptake. Additionally, it desensitizes hepatocytes to TNF-α-induced apoptosis by down-regulating the death-inducing signaling complex and facilitating the release of TNFRSF1A, while also suppressing the production of pro-inflammatory mediators such as TNF-α and IL-6. The compound further demonstrates calcium channel modulation properties by enhancing microsomal Ca-ATPase activity through the nitric oxide/cGMP pathway and blocking voltage- and receptor-operated calcium channels, contributing to its vasorelaxant and cytoprotective profiles at the molecular level.
2.PRODUCT INDICATIONS
This compound is indicated for non-clinical research applications spanning oncology, hepatology, endocrinology, and microbiology, where it is utilized to study cytotoxic mechanisms against specific cancer cell lines such as HL-60 and T47D, as well as hepatoprotective strategies against toxin-induced liver injury. Researchers employ 14-deoxyandrographolide to investigate insulin-potentiating effects and GLUT4 translocation for antidiabetic drug discovery, and to evaluate antimicrobial adjuvants that inhibit quorum sensing and biofilm formation in pathogens like Pseudomonas aeruginosa. Furthermore, it is widely used as a primary reference standard in chromatographic method development (HPLC/MS) for the quantitative analysis of Andrographis paniculataextracts, catering to botanists, analytical chemists, and toxicologists examining oxidative stress, lipid peroxidation, and glutathione homeostasis in cellular models.
3.CLINICAL EFFICACY OF PRODUCT
In extensive preclinical evaluations, 14-deoxyandrographolide has demonstrated significant efficacy by inhibiting the growth of human promyelocytic leukemia (HL-60) cells with a GI50 value of 25.46 µM and exhibiting selective cytotoxicity against breast cancer (T47D) cells with an EC50 of 2.8 µg/ml, while sparing non-malignant hepatic cells at similar concentrations. Animal studies confirm its potent antihyperglycemic capacity, showing marked reductions in blood glucose levels in streptozotocin-induced diabetic rats and db/db mice following oral administration at 100 mg/kg, alongside improved insulin sensitivity through enhanced GLUT4 membrane translocation. Moreover, the compound effectively mitigates ethanol-induced hepatosteatosis and liver injury by activating AMPK, down-regulating lipogenic enzymes (SREBP-1c, ACC, FAS), and restoring antioxidant defenses (GSH levels), establishing its robust therapeutic potential in metabolic and hepatic disorder models.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: 14-Deoxyandrographolide, Labdane Diterpene, Andrographis Paniculata, Anti-inflammatory, Anticancer, Hepatoprotective, AMPK Activator, Antidiabetic, Natural Product, Phytochemical, Research Chemical, Bioactive Compound, Calcium Channel Blocker, TNF-alpha Inhibitor
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