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Chemicals
Continentalic acid CAS NO.19889-23-7
<p>Continentalic acid is a high-purity diterpenic acid naturally derived from the roots of <em>Aralia continentalis</em>, supplied as a white to off-white crystalline powder ideal for advanced pharmacological research and chemical synthesis. This premium natural product serves as a critical reference standard and lead compound for scientists investigating anti-inflammatory, anticancer, and antimicrobial mechanisms, …
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Continentalic acid |
| CAS NO. | 19889-23-7 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C20H30O2 |
| Molecular Weight | 302.46 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in DMSO, Chloroform, Dichloromethane, Ethyl Acetate; slightly soluble in Methanol |
| Endotoxin | ≤10 EU/mg |
| Biological Activity | Diterpenic acid with anti-inflammatory, anti-bacterial (MRSA/MSSA), anti-diabetic, and anti-cancer (apoptosis inducer) properties |
| Storage Conditions | Store at -20°C, protected from light and moisture. Keep container tightly sealed. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Continentalic acid exerts its primary biological effects by potently suppressing the NF-κB signaling pathway, inhibiting the phosphorylation and degradation of IκBα to prevent the translocation of inflammatory mediators into the nucleus. Additionally, it triggers programmed cell death in malignant cells by activating caspase cascades and modulating Bcl-2 family proteins, while simultaneously downregulating key enzymes such as COX-2, iNOS, and matrix metalloproteinases (MMPs). This multi-target action allows it to disrupt critical survival signals in pathogens and abnormal cells, making it effective in attenuating oxidative stress and blocking the proliferation of drug-resistant bacteria like MRSA at the molecular level.
2.PRODUCT INDICATIONS
This compound is indicated primarily for use in preclinical research settings targeting chronic inflammatory conditions, various carcinogenic models, and infectious disease studies involving resistant bacterial strains. It is highly suitable for researchers exploring potential therapies for osteoarthritis, rheumatoid arthritis, B-cell lymphomas, and metabolic disorders, given its documented activity in chondrocyte protection and glucose regulation models. Furthermore, laboratory professionals utilizing this product often focus on dermatological applications, neuroprotection, and renal injury models, where its ability to inhibit neutrophil infiltration and reduce lipid peroxidation is of particular interest.
3.CLINICAL EFFICACY OF PRODUCT
In rigorous preclinical evaluations, continentalic acid has demonstrated significant efficacy by reducing the production of pro-inflammatory cytokines (such as IL-6, IL-8, and TNF-α) and effectively inducing apoptosis in aggressive cancer cell lines including HepG2, MCF-7, and B-cell lymphoma cells. Animal model studies confirm its therapeutic potential, showing marked improvements in renal function, reduced blood glucose and cholesterol levels in diabetic rats, and substantial protection against cartilage degradation in osteoarthritis-induced models. These findings highlight its strong inhibitory concentration (MIC 8-16 µg/mL) against clinical isolates of Staphylococcus aureusand its capability to enhance overall cellular homeostasis in research environments.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Continentalic Acid, Diterpenic Acid, Anti-inflammatory, Anticancer, Apoptosis Inducer, NF-κB Inhibitor, Aralia continentalis, Research Chemical, Pharmaceutical Intermediate, Natural Product, Lab Reagent, C20H30O2
If you have any product requirements, please send an email to:consult@huanqiukeji9.com
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