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Chemicals
Epimedin B CAS NO.110623-73-9
<p>Epimedin B is a high-purity prenylated flavonoid glycoside, predominantly isolated from various <em>Epimedium</em>species such as <em>Epimedium brevicornum</em>and <em>Epimedium koreanum</em>, supplied as a yellow crystalline powder strictly for non-clinical laboratory research. It serves as a critical phytochemical standard and a lead compound for scientists investigating the pharmacological potential of Herba E…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Epimedin B |
| CAS NO. | 110623-73-9 |
| Appearance | Yellow to yellow-green amorphous powder or crystals |
| Molecular Formula | C38H48O19 |
| Molecular Weight | 808.78 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in methanol, ethanol, DMSO; slightly soluble in water |
| Endotoxin | ≤5 EU/mg |
| Biological Activity | Icariin-like bioactivity, promoting osteoblast differentiation, anti-osteoporotic, neuroprotective, and potential anti-tumor effects |
| Storage Conditions | Store at -20°C, protected from light and moisture; stable for 24 months under proper storage |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The biological activity of Epimedin B is mediated through the modulation of several key signaling cascades, most notably by binding to Estrogen Receptor 1 (ESR1) to prevent its degradation, thereby suppressing osteoclast differentiation and bone resorption via the downregulation of MAPK and PI3K/AKT pathways. Concurrently, it activates the AMPK-Nrf2 signaling axis to enhance cellular antioxidant defenses, significantly reducing reactive oxygen species (ROS) production and mitigating oxidative stress-induced cellular damage. Furthermore, the compound influences melanogenesis by stabilizing and upregulating tyrosinase family proteins through the PKB/GSK3β/β-catenin and p38/ERK MAPK pathways, while also exerting anti-inflammatory effects by inhibiting the NF-κB and NOD-like receptor signaling routes to lower pro-inflammatory cytokine expression.
2.PRODUCT INDICATIONS
This product is indicated for preclinical research applications targeting professionals in osteology, dermatology, and inflammatory disease studies, including researchers modeling osteoporosis, diabetic bone loss, vitiligo, and neuroinflammation. It is particularly suitable for bone biologists studying the balance between osteoblast and osteoclast activity, as well as cosmetic scientists exploring natural agents for skin repigmentation and anti-aging formulations. Additionally, it serves as an essential standard for quality control and chromatographic method development in botanical extract analysis, and is applicable for immunologists and toxicologists conducting cell-based screenings to evaluate the therapeutic potential of flavonoids against metabolic disorders and oxidative injuries in controlled laboratory environments.
3.CLINICAL EFFICACY OF PRODUCT
As a raw botanical reference standard not formulated for human therapeutic use, Epimedin B does not possess approved clinical efficacy, yet it demonstrates significant bioactivity in extensive preclinical in vitro and animal model studies. Experimental data indicate that it effectively prevents ovariectomy-induced and diabetic osteoporosis in rodent models by maintaining bone microarchitecture and suppressing bone resorption, with efficacy comparable to standard estrogen therapy in specific parameters. Additionally, research confirms its capacity to promote melanosome maturation and melanin synthesis in depigmentation models, inhibit NLRP3 inflammasome-driven inflammation, and protect neuronal function in neurotoxic environments, validating its strong pharmacological profile as a research tool and a promising lead compound for future drug development rather than a direct clinical treatment.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Flavonoid Glycoside, Phytochemical, Anti-osteoporotic, Anti-inflammatory, Antioxidant, Melanogenesis, Osteoblast, Research Chemical, Natural Product, Bone Health, Tyrosinase, Epimedium.
If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157
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