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Chemicals
Endothelin (16-21) CAS NO.121377-67-1
<p>Endothelin (16-21), commonly known as the Endothelin C-terminal Hexapeptide, is a potent and selective ETB receptor agonist derived from the endogenous endothelin-1 sequence. This short synthetic peptide retains high bioactivity despite its minimal structure, making it an essential pharmacological tool for researchers studying receptor-specific signaling pathways in cardiovascular and pulmonary systems without th…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Endothelin (16-21) |
| CAS NO. | 121377-67-1 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₃₉H₅₇N₉O₉ |
| Molecular Weight | 804.0g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in 1M acetic acid, DMSO, or deionized water |
| Endotoxin | ≤1 EU/mg |
| Biological Activity | Potent and selective ETB receptor agonist; induces smooth muscle contraction |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide functions as a full agonist that selectively binds and activates endothelin ETB receptors with high affinity (EC50 ~228 nM in guinea pig bronchus), while exhibiting negligible activity at ETA receptors. Its mechanism involves triggering Gq-protein coupled signaling, leading to a rapid increase in intracellular calcium concentration, which subsequently induces smooth muscle contraction and modulates vascular and bronchial tone in experimental models.
2.PRODUCT INDICATIONS
This hexapeptide is indicated for in vitro and ex vivo research applications focused on ETB receptor-mediated physiology and pathology. It is widely used by pharmacologists and vascular biologists to investigate disease mechanisms in pulmonary hypertension, asthma (airway hyperreactivity), and systemic hypertension, as well as for screening novel endothelin receptor antagonists and studying smooth muscle contractility in isolated tissue preparations.
3.CLINICAL EFFICACY OF PRODUCT
Although not intended for clinical use, Endothelin (16-21) has demonstrated high efficacy in preclinical research as a selective probe. Studies confirm its ability to potently induce ETB-mediated contractions in bronchial and vascular smooth muscle, providing robust data for validating receptor-specific responses and establishing proof-of-concept for ETB-targeted therapeutic strategies in cardiorespiratory diseases.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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