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Chemicals
Aristolochic acid C CAS NO.4849-90-5
<p>Aristolochic acid C is a nitrophenanthrene carboxylic acid alkaloid derived from plants of the Aristolochiaceae family, typically supplied as a yellow to light brown crystalline solid intended strictly for controlled laboratory environments. As a defined derivative of aristolochic acid, this research chemical is characterized by its distinct structural profile featuring a nitro group and a phenanthrene core, maki…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Aristolochic acid C |
| CAS NO. | 4849-90-5 |
| Appearance | Yellow to light brown crystalline solid |
| Molecular Formula | C16H9NO7 |
| Molecular Weight | 327.25 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in DMSO, methanol; slightly soluble in ethanol |
| Endotoxin | ≤10 EU/mg |
| Biological Activity | Phospholipase A2 (PLA2) inhibitor; Anti-proliferative activity against certain cancer cell lines |
| Storage Conditions | -20°C, protected from light, sealed and dry |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The biological activity of Aristolochic acid C is largely attributed to its capacity to act as a phospholipase A2 (PLA2) inhibitor, interfering with enzymatic processes that release arachidonic acid and subsequently modulate inflammatory responses and cellular signaling cascades. Additionally, it exhibits cytotoxic properties by interacting with DNA and inducing oxidative stress within cells, which can lead to cell cycle arrest and apoptosis in susceptible cancer cell lines. This dual mechanism involving enzyme inhibition and direct genotoxic effects provides a molecular basis for its potential role in studying anti-tumor activities and the toxicological mechanisms underlying aristolochic acid nephropathy in research settings.
2.PRODUCT INDICATIONS
Aristolochic acid C is specifically indicated for use in scientific research applications focused on toxicology, pharmacology, and natural product chemistry, particularly for studies exploring the mechanisms of bioactivation of aristolochic acids and their associated nephrotoxic and carcinogenic risks. It serves as a critical reference standard for developing analytical methods to detect these compounds in herbal supplements and environmental samples, catering to researchers in academic institutions and regulatory agencies. Furthermore, it is suitable for in vitro screening assays aimed at evaluating the anti-proliferative effects of aristolochic acid derivatives on various human cancer cell lines, supporting exploratory investigations into potential therapeutic leads while emphasizing strict safety protocols.
3.CLINICAL EFFICACY OF PRODUCT
While Aristolochic acid C is not approved for clinical use due to significant safety concerns, including nephrotoxicity and carcinogenicity, its efficacy in a research context lies in its utility as a model compound for understanding the pathophysiology of aristolochic acid-induced diseases. Preclinical studies have demonstrated its ability to induce DNA damage and modulate cellular signaling pathways relevant to cancer progression, providing valuable insights into the molecular basis of its toxicity. These findings contribute to the broader knowledge base regarding the risks associated with aristolochic acid-containing herbal medicines and inform the development of strategies to mitigate exposure, rather than serving as a therapeutic agent for clinical applications.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: AristolochicAcidC ,Toxicology ,Pharmacology ,ResearchChemical ,PLA2Inhibitor ,NaturalProducts ,DNADamage ,CancerResearch ,ReferenceStandard ,LabSupplies
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