Image not available
Chemicals
Succinyl-(Glu9,Ala11,15)-Endothelin-1 (8-21) CAS NO.142569-99-1
<p>Succinyl-(Glu9,Ala11,15)-Endothelin-1 (8-21), widely known in research as IRL-1620 or Sovateltide, is a potent and highly selective synthetic peptide agonist targeting the Endothelin B (ET<sub>B</sub>) receptor. This modified fragment of Endothelin-1 is engineered with specific amino acid substitutions (Glu9, Ala11,15) and an N-terminal succinyl group to enhance receptor specificity and metabolic stability. It is…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
Source categories
About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Succinyl-(Glu9,Ala11,15)-Endothelin-1 (8-21) |
| CAS NO. | 142569-99-1 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C86H117N17O27 |
| Molecular Weight | 1821.0g/mol |
| Purity (RP-HPLC) | ≥95% |
| Solubility | Soluble in water, DMSO, or 1M acetic acid |
| Endotoxin | ≤1 EU/mg |
| Biological Activity | Selective ETBreceptor agonist (Ki ~16 pM) |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
IRL-1620 functions by selectively binding to the Endothelin B receptor (ETB) with high affinity (Ki ≈ 16 pM), while exhibiting minimal interaction with the ETA receptor subtype. Upon binding, it activates Gq-protein coupled signaling, leading to phospholipase C activation, intracellular calcium mobilization, and the production of nitric oxide (NO) and prostacyclin via endothelial cells. This cascade results in potent vasodilation, increased local blood flow, and modulation of vascular permeability. Its mechanism is distinct from full-length endothelin-1, as it avoids the vasoconstrictive effects typically mediated by ETA receptors, making it a precise pharmacological tool for isolating ETBreceptor functions in experimental settings.
2.PRODUCT INDICATIONS
This peptide is indicated for preclinical research applications focused on the endothelin system, particularly for studies investigating cerebral ischemia, stroke, neurodegenerative diseases, and cancer. Researchers use IRL-1620 to explore its potential neuroprotective effects, angiogenesis modulation, and targeted drug delivery strategies that leverage ETBreceptor overexpression in tumor vasculature. It is suitable for academic, pharmaceutical, and biotechnology laboratories engaged in drug discovery for cardiovascular disorders, neurovascular coupling, and conditions where selective ETBreceptor activation is therapeutically relevant.
3.CLINICAL EFFICACY OF PRODUCT
Although not approved for clinical use, IRL-1620 has demonstrated significant efficacy in numerous preclinical models. Studies have shown that it can improve neurological outcomes and reduce infarct volume in rodent models of cerebral ischemia and stroke by enhancing cerebral blood flow. In oncology research, it has been investigated for its ability to enhance the delivery of chemotherapeutic agents to tumors via ETBreceptor-mediated vascular effects. The peptide’s high selectivity and potency make it a valuable benchmark compound for validating the therapeutic potential of ETBreceptor targeting in early-stage translational research.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: IRL1620, #Sovateltide, #EndothelinReceptor, #ETBAgonist, #Vasodilation, #Neuroprotection, #CerebralBloodFlow, #PeptideResearch, #CardiovascularResearch, #OncologyResearch, #ResearchChemical, #SyntheticPeptide, #GProteinCoupledReceptor, #Neurovascular, #Ischemia, #StrokeResearch, #BiochemicalTool, #PreclinicalResearch
If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85244969439
More from this supplier
Global Technology Co., Ltd.
