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Chemicals
[Arg8]-a-Neo-Endorphin (1-8) CAS NO.75106-72-8
<p>[Arg8]-α-Neo-Endorphin (1-8) is a synthetic analog of the endogenous opioid peptide α-Neoendorphin, specifically engineered with an arginine substitution at position 8 to enhance receptor binding affinity and metabolic stability. This octapeptide retains the core Tyr-Gly-Gly-Phe opioid motif, allowing it to interact potently with κ-opioid receptors (KOR) and μ-opioid receptors (MOR) in the central nervous system.…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Arg8]-a-Neo-Endorphin (1-8) |
| CAS NO. | 75106-72-8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₄₆H₇₃N₁₅O₁₀ |
| Molecular Weight | 1036.2g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in 1M acetic acid, DMSO, or deionized water |
| Endotoxin | ≤1 EU/mg |
| Biological Activity | Potent agonist for κ-opioid receptors (KOR) |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide functions as a potent agonist at G protein-coupled opioid receptors, with a pronounced preference for the κ-opioid receptor (KOR) subtype. Upon binding, it inhibits adenylate cyclase activity, reducing intracellular cAMP levels and leading to neuronal hyperpolarization via the opening of potassium channels. This mechanism effectively suppresses neurotransmitter release (e.g., glutamate and substance P) in pain-processing pathways, resulting in antinociceptive and potential dysphoric effects characteristic of KOR activation.
2.PRODUCT INDICATIONS
This product is strictly for Research Use Only (RUO) and is indicated for in vitro and preclinical studies targeting the opioid system. It is ideal for scientists in neuropharmacology and drug discovery who require a stable, high-affinity ligand for receptor binding assays, functional cAMP accumulation tests, and animal model studies of analgesia. The [Arg8] modification makes it particularly suitable for experiments requiring enhanced enzymatic stability compared to the native peptide sequence.
3.CLINICAL EFFICACY OF PRODUCT
As a research chemical, [Arg8]-α-Neo-Endorphin (1-8) is not intended for human therapeutic use and has no approved clinical efficacy data. In experimental settings, this analog demonstrates superior and prolonged analgesic efficacy in rodent models of inflammatory and neuropathic pain compared to unmodified fragments. Its enhanced stability translates to longer-lasting behavioral effects, providing robust preclinical data for the development of novel opioid-based therapeutics.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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Global Technology Co., Ltd.
