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![[D-Arg6] – Dynorphin A (1 – 13), porcine CAS NO.75921-87-8](https://images.cnmqh.com/images/a10134/9118547a021df7038ddc4a48a2efd520-20260427024232.webp)
Chemicals
[D-Arg6] – Dynorphin A (1 – 13), porcine CAS NO.75921-87-8
<p>[D-Arg⁶]-Dynorphin A (1-13), porcine is a strategically engineered analog of the endogenous neuropeptide, where the substitution of the 6th amino acid with a D-arginine confers exceptional resistance to enzymatic degradation. This modification significantly extends its metabolic half-life in research settings while retaining high affinity and selectivity for the kappa-opioid receptor (KOR). It serves as a potent …
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [D-Arg6] - Dynorphin A (1 - 13), porcine |
| CAS NO. | 75921-87-8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₇₅H₁₂₆N₂₄O₁₅ |
| Molecular Weight | 1600.9g/mol |
| Purity (RP-HPLC) | ≥95% |
| Solubility | Soluble in water, dilute acetic acid, or 1M NaOH |
| Endotoxin | ≤1 EU/mg |
| Biological Activity | Potent endogenous kappa-opioid receptor (KOR) agonist |
| Storage Conditions | Store at -20°C, protected from moisture and light |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide functions as a highly selective kappa-opioid receptor (KOR) agonist, binding preferentially to KOR with minimal cross-reactivity to mu or delta opioid receptors. Upon binding, it activates the Gi/o protein-coupled pathway, leading to the inhibition of adenylate cyclase and a reduction in intracellular cAMP levels. This action modulates neuronal excitability by inhibiting voltage-gated calcium channels and promoting potassium efflux, resulting in the suppression of neurotransmitter release and the dampening of pain signal transmission within the central nervous system.
2.PRODUCT INDICATIONS
[D-Arg⁶]-Dynorphin A (1-13) is indicated for preclinical research focused on the kappa-opioid receptor system. It is widely used in studies of neuropathic and inflammatory pain models, addiction and reward pathways, as well as stress-related behaviors such as depression and anxiety. The peptide is particularly valuable for researchers seeking to develop non-addictive analgesic alternatives, as KOR activation produces analgesia without the typical mu-opioid receptor-associated risks of respiratory depression and physical dependence.
3.CLINICAL EFFICACY OF PRODUCT
In experimental models, this analog demonstrates potent and prolonged analgesic effects in both acute and chronic pain paradigms due to its enhanced stability. It effectively reduces pain-related behaviors in rodent models of nerve injury and inflammation. Additionally, it modulates dysphoric states and drug-seeking behaviors in addiction studies, although its effects on mood are dose-dependent, with higher doses potentially inducing aversive responses, which is a characteristic area of study for KOR agonists.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: DynorphinA, #KappaOpioidReceptor, #KORagonist, #Neuropeptide, #PainResearch, #Neuroscience, #PeptideAnalogue, #DArg6, #OpioidResearch
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