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Chemicals
Prodynorphin (228-240), porcine CAS NO.85006-82-2
<p>Prodynorphin (228-240), porcine, also known as Rimorphin or Dynorphin B (1-13), is an endogenous neuropeptide fragment derived from the prodynorphin precursor. It features the conserved N-terminal opioid motif (Tyr-Gly-Gly-Phe-Leu) essential for receptor binding, followed by a unique C-terminal extension that confers high selectivity for the kappa-opioid receptor (KOR). This peptide is widely utilized in neurosci…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Prodynorphin (228-240), porcine |
| CAS NO. | 85006-82-2 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₇₄H₁₁₅N₂₁O₁₇ |
| Molecular Weight | 1608.9g/mol |
| Purity (RP-HPLC) | ≥95% |
| Solubility | Soluble in water, dilute acetic acid, or 1M NaOH |
| Endotoxin | ≤1 EU/mg |
| Biological Activity | Potent endogenous kappa-opioid receptor (KOR) agonist |
| Storage Conditions | Store at -20°C, protected from moisture and light |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide exerts its effects by selectively binding to the kappa-opioid receptor (KOR), a Gi/o protein-coupled receptor. Upon binding, it inhibits adenylate cyclase activity, reducing intracellular cAMP levels, and modulates ion channel function by inhibiting voltage-gated calcium channels and activating G protein-coupled inwardly rectifying potassium (GIRK) channels. This leads to neuronal hyperpolarization and presynaptic inhibition of neurotransmitter release (e.g., glutamate, dopamine), which underlies its physiological effects on analgesia and mood regulation.
2.PRODUCT INDICATIONS
Prodynorphin (228-240), porcine is indicated for preclinical research applications focused on the central nervous system. It is primarily used in studies investigating neuropathic pain, stress-induced behaviors, depression, anxiety, and drug addiction mechanisms. Researchers utilize this peptide to explore KOR's role in modulating the reward pathway and to develop novel non-addictive analgesic and anti-addiction therapies, making it essential for neuropharmacology and psychiatric disorder research.
3.CLINICAL EFFICACY OF PRODUCT
In experimental models, Prodynorphin (228-240) demonstrates significant KOR-mediated analgesic efficacy in chronic pain and neuropathic pain paradigms. It also shows modulatory effects on affective behaviors, reducing stress responses and drug-seeking behavior in addiction models. However, its efficacy is dose-dependent, as high concentrations can induce dysphoric or aversive effects, highlighting its utility in studying the complex biphasic nature of the dynorphin/KOR system.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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