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Chemicals
Lys-(Hyp3)-Bradykinin CAS NO.113662-39-8
<p>Lys-(Hyp³)-Bradykinin is a naturally occurring kinin peptide and a potent bradykinin B₂ receptor agonist, originally isolated from human urine. It features a key structural modification with 4-hydroxyproline (Hyp) at position 3, which enhances its stability and receptor interaction compared to standard bradykinin. This high-purity research-grade peptide is specifically designed for scientists studying the kallikr…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Lys-(Hyp3)-Bradykinin |
| CAS NO. | 113662-39-8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₅₆H₈₅N₁₇O₁₃ |
| Molecular Weight | 1216.4g/mol |
| Purity (RP-HPLC) | ≥95% |
| Solubility | Soluble in water or 0.1% TFA in water; soluble in dilute acetic acid |
| Endotoxin | ≤1 EU/mg (or as per batch testing) |
| Biological Activity | Potent bradykinin B₂ receptor agonist; modulates vascular permeability and inflammation responses |
| Storage Conditions | Store at -20°C, protected from light and moisture; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide exerts its effects by selectively binding to the constitutively expressed bradykinin B₂ receptor (B₂R), a G protein-coupled receptor (GPCR). This binding activates the Gq/11 signaling pathway, stimulating phospholipase C (PLC) and leading to the production of inositol trisphosphate (IP₃) and diacylglycerol (DAG). The subsequent release of intracellular calcium and activation of protein kinase C (PKC) drives downstream effects such as nitric oxide (NO) synthesis, prostaglandin release, and MAPK pathway activation, which collectively mediate vasodilation, smooth muscle contraction, and pain signaling.
2.PRODUCT INDICATIONS
Lys-(Hyp³)-Bradykinin is indicated for preclinical research applications focusing on inflammation, vascular permeability, pain mechanisms, and cardiovascular regulation. It serves as a reliable positive control in receptor binding assays and functional studies using isolated tissues (e.g., vascular rings, ileum). Researchers utilize it to model acute inflammatory responses, study endothelial dysfunction in hypertension or sepsis, and screen for novel B₂ receptor antagonists in drug discovery pipelines.
3.CLINICAL EFFICACY OF PRODUCT
In experimental models, Lys-(Hyp³)-Bradykinin demonstrates high efficacy in inducing B₂ receptor-mediated physiological responses, including potent vasodilation, increased vascular permeability leading to edema, and sensitization to pain (hyperalgesia). Studies in human fibroblasts and smooth muscle cells confirm its ability to stimulate inositol phosphate accumulation and cAMP production with potency comparable to native bradykinin. While not a therapeutic agent itself, its robust agonist activity makes it a critical tool for validating the B₂ receptor as a target in inflammatory and cardiovascular disease research.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: LysHyp3Bradykinin, #BradykininAgonist, #B2Receptor, #KininSystem, #VascularResearch, #InflammationResearch, #PainResearch, #GPCRResearch, #ResearchPeptide, #CellSignaling
If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85244969439
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