Image not available
![[Pyr1] – Apelin-13 CAS NO.217082-60-5](https://images.cnmqh.com/images/a10134/a42a4f16c1cd2b1f8085f609dc85059f-20260421014301.webp)
Chemicals
[Pyr1] – Apelin-13 CAS NO.217082-60-5
<p>[Pyr1]-Apelin-13 is a pyroglutamate-modified (N-terminal pGlu) variant of the endogenous apelin-13 peptide, representing the predominant and most stable circulating isoform found in human plasma and cardiac tissue. As a potent and selective endogenous agonist for the G protein-coupled APJ receptor, it serves as a high-value research tool for cardiovascular pharmacology, neurobiology, and metabolic studies, offeri…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
Source categories
About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Pyr1] - Apelin-13 |
| CAS NO. | 217082-60-5 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₆₉H₁₀₈N₂₂O₁₆S |
| Molecular Weight | 1551.7g/mol |
| Purity (RP-HPLC) | ≥95% |
| Solubility | Soluble in water, 0.1 M acetic acid, or 10% DMSO solution |
| Endotoxin | <1 EU/mg |
| Biological Activity | Potent and selective endogenous agonist for the APJ receptor; induces vasodilation, enhances cardiac contractility, and activates AMPK/eNOS signaling pathways |
| Storage Conditions | Store at -20°C, protected from light and moisture; stable for at least 2 years |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide exerts its effects by selectively binding to the apelin receptor (APJ) with high affinity, activating Gαi and Gαq signaling pathways. This engagement triggers downstream phosphorylation of Akt and ERK, stimulates endothelial nitric oxide synthase (eNOS), and activates AMP-activated protein kinase (AMPK). The net result is potent vasodilation, increased cardiac contractility, and suppression of oxidative stress. The N-terminal pyroglutamate modification protects the peptide from rapid degradation by aminopeptidases, prolonging its half-life and biological activity in physiological systems.
2.PRODUCT INDICATIONS
This product is indicated for preclinical research focused on cardiovascular diseases, including heart failure, hypertension, and myocardial ischemia-reperfusion injury. It is also utilized in studies of fluid homeostasis, metabolic syndrome, neuropathic pain, and neuroinflammation. Researchers employ [Pyr1]-Apelin-13 to investigate APJ receptor trafficking, develop biased agonism assays, and screen for novel therapeutics targeting the apelinergic system.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical data demonstrate that [Pyr1]-Apelin-13 significantly improves cardiac output and ejection fraction in animal models of heart failure while reducing peripheral vascular resistance. It attenuates myocardial fibrosis, oxidative damage, and apoptosis following ischemic insult. In models of neuropathic pain and spinal cord injury, it reduces mechanical allodynia and microglial activation. While not yet approved for human use, its robust cardioprotective and anti-inflammatory efficacy in translational models supports its role as a critical reference standard for drug discovery.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Pyr1Apelin13 #ApelinReceptor #APJagonist #CardiovascularResearch #Vasodilation #CardiacContractility #NeuropathicPain #MetabolicResearch
If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85244969439
More from this supplier
Global Technology Co., Ltd.
