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Chemicals
4´,5,7-Trimethoxyflavone CAS NO.5631-70-9
<p>4',5,7-Trimethoxyflavone is a high-purity polymethoxyflavone (PMF) derived from the Kaempferia parviflora plant, standardized to support cellular health and metabolic function. This potent flavonoid is characterized by its three methoxy groups, which enhance its stability and bioavailability compared to common hydroxylated flavonoids. It is primarily utilized in research settings for its ability to modulate k…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | 4´,5,7-Trimethoxyflavone |
| CAS NO. | 5631-70-9 |
| Appearance | Off-white to light yellow powder |
| Molecular Formula | C18H16O5 |
| Molecular Weight | 312.32 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in DMSO, methanol; slightly soluble in ethanol; insoluble in water |
| Endotoxin | <0.01 EU/mg |
| Biological Activity | Acts as a CFTR chloride channel activator; modulates oxidative stress pathways; potential anti-inflammatory and neuroprotective properties |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The compound exerts its effects through a multi-target mechanism, primarily acting as a CFTR chloride channel activator to regulate ion transport and fluid secretion in epithelial cells. It also functions as an acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitor, which supports cognitive function research by increasing acetylcholine levels. Additionally, it modulates apoptosis pathways by upregulating Bax/Bcl-xL ratios and activating caspase-3, indicating a pro-apoptotic effect on abnormal cells. Its antioxidant activity is demonstrated through the scavenging of free radicals and suppression of reactive oxygen species (ROS) and inflammatory mediators like TNF-α, providing a protective mechanism against oxidative damage in dermal fibroblasts and other cell types.
2.PRODUCT INDICATIONS
This flavone is indicated for research applications in neuroprotection, anti-aging dermatology, and metabolic health. It is suitable for studies investigating natural interventions for cognitive decline, given its cholinesterase inhibitory properties. In skin health research, it is used to model protection against UV-induced oxidative stress and collagen degradation. Furthermore, its CFTR activation profile makes it relevant for investigations into respiratory health and electrolyte transport disorders. The product is intended for use by researchers, academic institutions, and R&D departments in the nutraceutical and pharmaceutical industries focusing on developing natural-based solutions for chronic inflammatory conditions and age-related cellular decline.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical studies demonstrate that 4',5,7-Trimethoxyflavone significantly inhibits the proliferation of gastric cancer cells (e.g., SNU-16) by inducing ER stress-mediated apoptosis. In models of skin aging, it effectively reduces TNF-α-induced ROS production and inflammatory cytokine release in human dermal fibroblasts, preserving cell viability under oxidative stress. Cognitive efficacy is supported by its inhibitory action on AChE and BChE, enhancing cholinergic transmission. While current evidence is primarily derived from in vitro and animal models, these results highlight its potential as a multi-functional agent for supporting cellular resilience, with the most robust data existing in the areas of anti-proliferation and antioxidant defense.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
HotTags:Flavonoid, Polymethoxyflavone, NaturalCompound, ResearchChemical, Antioxidant, CFTRActivator, KaempferiaParviflora, HPLCPure, MetabolicHealth, Neuroprotection, PreclinicalResearch, Phytochemical, Supplier, Manufacturer, Bulk order, Pharmaceutical.
If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553
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