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Chemicals
AICA Ribonucleotide (AICAR)
<p>AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a cell-permeable AMPK activator widely used in metabolic and sports science research. It mimics the physiological effects of exercise by activating AMP-activated protein kinase, thereby enhancing glucose uptake, stimulating fatty acid oxidation, and promoting energy homeostasis. This compound is particularly valuable for studying insulin sensitivity, endura…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | AICA Ribonucleotide (AICAR) |
| CAS NO. | 2627-69-2 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₉H₁₃N₄O₅P |
| Molecular Weight | 288.19 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water, DMSO, and alkaline buffers; slightly soluble in methanol |
| Endotoxin | ≤ 0.05 EU/mg (Suitable for cell culture and in vitro studies) |
| Biological Activity | AMPK activator; mimics exercise-induced metabolic effects, promotes glucose uptake and fatty acid oxidation |
| Storage Conditions | Store at 2–8°C, protected from light and moisture; stable for 24–36 months when sealed properly |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
AICAR functions as an analog of adenosine monophosphate (AMP) and is phosphorylated intracellularly to ZMP (ZMP carboxamide), which mimics AMP and allosterically activates AMP-activated protein kinase (AMPK). This activation triggers downstream signaling pathways that promote catabolic processes such as fatty acid oxidation and glucose uptake while inhibiting anabolic pathways like lipid and protein synthesis. By mimicking the cellular energy deficit state, AICAR effectively reprograms metabolism to enhance energy efficiency and cellular survival, making it a powerful tool for studying metabolic adaptation, insulin resistance, and exercise mimetics in both in vitro and in vivo models.
2.PRODUCT INDICATIONS
AICAR is primarily indicated for research purposes in metabolic disease modeling, sports science, and aging-related studies. It is used to investigate mechanisms of insulin resistance, type 2 diabetes, obesity, and muscle performance enhancement. Additionally, AICAR serves as a valuable tool in cardiovascular and neurodegenerative research due to its protective effects on mitochondrial function and cellular energy homeostasis. Researchers in academia and industry utilize AICAR to evaluate potential therapeutic interventions targeting metabolic dysregulation, endurance training effects, and age-associated decline in physical capacity.
3.CLINICAL EFFICACY OF PRODUCT
Although not approved for human clinical use, AICAR has demonstrated significant efficacy in preclinical models for improving glucose tolerance, reducing body fat, and enhancing exercise endurance. In animal studies, AICAR administration has been shown to increase treadmill running time, improve insulin sensitivity, and reduce adipose tissue mass. These findings support its potential as a metabolic modulator, though clinical translation remains limited due to pharmacokinetic challenges and safety concerns. Current research continues to explore its efficacy in controlled human trials for metabolic syndrome and performance optimization, positioning AICAR as a promising but investigational compound in metabolic pharmacology.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157
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