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Chemicals
IDR-1 CAS NO.940291-10-1
<p>IDR-1 (Innate Defense Regulator 1) is a synthetic 13-amino acid immunomodulatory peptide derived from bactenecin, designed to enhance the host's innate immune response without direct antibiotic activity. It functions as a cationic host defense peptide that selectively modulates immune signaling pathways, making it a valuable research tool for studying anti-infective strategies and immune regulation in preclin…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | IDR-1 |
| CAS NO. | 940291-10-1 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₆₅H₁₁₈N₁₈O₁₅ |
| Molecular Weight | 1379.7 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, PBS, and dilute acids; insoluble in nonpolar solvents |
| Endotoxin | ≤1 EU/mg (or as per customer specification) |
| Biological Activity | Potent immunomodulator; enhances innate defense without direct antimicrobial activity |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
IDR-1 acts primarily on monocytes and macrophages, enhancing chemokine production (e.g., monocyte chemoattractants) while suppressing excessive pro-inflammatory cytokine release. It interacts with intracellular signaling pathways (e.g., NF-κB and MAPK) and has been shown to engage formyl peptide receptors (FPR) on neutrophils to promote chemotaxis without inducing harmful oxidative bursts, thereby rebalancing the immune response to favor pathogen clearance over destructive inflammation.
2.PRODUCT INDICATIONS
This peptide is indicated for research into bacterial infections, sepsis, and immunomodulation, particularly against multidrug-resistant pathogens like MRSA and vancomycin-resistant Enterococcus. It is used by immunologists, infectious disease researchers, and pharmaceutical R&D teams to develop novel anti-infective therapies that leverage host-directed mechanisms rather than direct microbial killing.
3.CLINICAL EFFICACY OF PRODUCT
In rodent models of heart failure and hypertension, Adrenomedullin infusion consistently demonstrates rapid hemodynamic improvement, including reduced systemic and pulmonary arterial pressure, improved cardiac output, and normalized renal perfusion. It effectively attenuates cardiac hypertrophy and fibrosis while protecting against acute kidney injury by reducing oxidative stress and inflammation. Although human recombinant forms are in clinical trials, the rat-specific peptide remains a gold standard for validating therapeutic efficacy and safety in murine systems.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Adrenomedullin #RatAdrenomedullin #VasodilatorPeptide #CardiorenalResearch #HypertensionResearch #HeartFailureModel #ResearchPeptide #SepticShock #CGRPfamily #cAMP
If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85296236544
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Global Technology Co., Ltd.
