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Chemicals
Euphorbia factor L3 CAS NO.218916-52-0
<p>Euphorbia Factor L3 (EFL3), also known as 5,15-Diacetyl-3-benzoyllathyrol, is a high-purity natural lathyrane diterpenoid extracted from the seeds of <em>Euphorbia lathyris</em>(Caper Spurge). As a potent bioactive small molecule, it is primarily utilized in scientific research for its dual pharmacological profile, demonstrating significant anti-tumor activity by inducing apoptosis and notable anti-inflammatory e…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Euphorbia factor L3 |
| CAS NO. | 218916-52-0 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C31H38O7 |
| Molecular Weight | 522.63 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in DMSO, methanol, and ethanol; slightly soluble in water |
| Endotoxin | < 0.1 EU/mg |
| Biological Activity | Potent anti-tumor and anti-inflammatory activity; induces apoptosis, inhibits NF-κB and STAT3 pathways |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Euphorbia Factor L3 exerts its effects through multiple molecular pathways. In oncology research, it triggers cancer cell apoptosis via the mitochondrial pathway, characterized by the loss of mitochondrial membrane potential and the release of cytochrome c, while also inhibiting cell proliferation through the ATF4-CHOP endoplasmic reticulum stress pathway. In inflammation models, EFL3 suppresses the activation of the NLRP3 inflammasome and the NF-κB signaling pathway, reducing the production of pro-inflammatory cytokines such as IL-1β, TNF-α, and nitric oxide (NO), with Rac1 identified as a potential target for its anti-arthritic effects.
2.PRODUCT INDICATIONS
This compound is indicated for preclinical research in two major therapeutic areas. For cancer studies, it is applied in assays involving lung cancer (A549), pancreatic cancer, and other tumor cell lines to evaluate its cytotoxic and anti-proliferative properties. In inflammatory and autoimmune disease research, EFL3 is used in models of rheumatoid arthritis, gouty arthritis, and general inflammation to assess its ability to alleviate joint swelling, synovial hyperplasia, and cytokine storms, serving as a lead compound for developing novel anti-inflammatory agents.
3.CLINICAL EFFICACY OF PRODUCT
While currently at the research stage, preclinical data robustly supports the therapeutic potential of Euphorbia Factor L3. In vitro studies show potent cytotoxicity against A549 lung cancer cells with IC50 values around 34 μM, and in vivo experiments using collagen-induced arthritis (CIA) mouse models demonstrate significant reduction in joint inflammation and bone destruction. These promising efficacy results position EFL3 as a strong candidate for further drug development, particularly for conditions requiring combined anti-proliferative and anti-inflammatory intervention.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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