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Chemicals
Baceridin CAS NO.1622872-91-6
<p>Baceridin is a naturally derived cyclic hexapeptide originally isolated from Epiphytic Bacillusspecies, classified as a potent proteasome inhibitor for preclinical research. It is characterized by its unique p53-independent mechanism, which allows it to induce apoptosis even in tumor cells with defective p53 signaling pathways. This research-grade compound is primarily utilized in oncology studies to investigate …
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Baceridin |
| CAS NO. | 1622872-91-6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₃₇H₅₇N₇O₆ |
| Molecular Weight | 695.9 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in DMSO, dimethylformamide; sparingly soluble in water |
| Endotoxin | ≤10 EU/mg (as determined by LAL assay) |
| Biological Activity | Inhibits proteasome chymotrypsin-like activity; induces p53-independent apoptosis in tumor cells |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Baceridin functions by selectively inhibiting the 20S proteasome's chymotrypsin-like activity, leading to the intracellular accumulation of polyubiquitinated proteins and disruption of the ubiquitin-proteasome system. This inhibition triggers a p53-independent apoptotic pathway, activating caspases and inducing cell cycle arrest at the G2/M phase. Unlike many conventional chemotherapeutic agents, its action does not rely on functional p53 tumor suppressor protein, allowing it to effectively target a broader range of cancer cell types, including those with common p53 mutations.
2.PRODUCT INDICATIONS
This product is indicated for in vitro and in vivo research applications focused on oncology, particularly for studying proteasome function, apoptosis induction, and cell cycle regulation. It is suitable for investigating drug resistance mechanisms in p53-mutated cancers, screening for synergistic effects with other anticancer agents, and exploring novel targeted therapy approaches. The primary user base includes cancer biologists, medicinal chemists, and pharmaceutical R&D teams engaged in early-stage drug discovery and mechanism-of-action studies.
3.CLINICAL EFFICACY OF PRODUCT
In preclinical studies, Baceridin has demonstrated significant efficacy in reducing cancer cell viability and inducing apoptosis across various cell lines, independent of their p53 status. Research data indicate that it effectively suppresses tumor growth in experimental models by blocking proteasomal degradation, leading to the accumulation of pro-apoptotic proteins. While currently restricted to research use, its ability to bypass common resistance mechanisms associated with p53 mutations positions it as a promising candidate for further therapeutic development.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Baceridin #ProteasomeInhibitor #CyclicHexapeptide #CancerResearch #Apoptosis #p53Independent #ResearchPeptide #DrugDiscovery #OncologyResearch #Proteasome
If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85296236544
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Global Technology Co., Ltd.
