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Chemicals
Pilocarpini nitras CAS NO.148-72-1
<p>Pilocarpini nitras (Pilocarpine Nitrate) is a direct-acting cholinergic muscarinic agonist available in oral tablet and ophthalmic solution forms. As a prescription pharmaceutical, it is primarily indicated for the symptomatic treatment of xerostomia (dry mouth) caused by radiotherapy for head and neck cancer or Sjögren's syndrome, as well as for lowering intraocular pressure in various types of glaucoma. The…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Pilocarpini nitras |
| CAS NO. | 148-72-1 |
| Appearance | White to almost white powder or crystalline powder |
| Molecular Formula | C11H17N3O5 |
| Molecular Weight | 271.27 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water; slightly soluble in ethanol; insoluble in ether and chloroform |
| Endotoxin | Complies with USP/EP injectable grade limits (< 5 EU/mg) |
| Biological Activity | Potent M3 muscarinic receptor agonist |
| Storage Conditions | Store at room temperature (15–30°C), protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The pharmacological effect of Pilocarpine Nitrate is mediated through its direct agonism of muscarinic (M-cholinergic) receptors located on the surface of target cells. In the context of oral administration, it binds to receptors on salivary and sweat glands, triggering a parasympathomimetic response that results in a significant increase in saliva, sweat, and other exocrine secretions. When applied topically to the eye, it acts on the iris sphincter and ciliary muscles, causing miosis (pupil constriction) and contraction of the ciliary body, which in turn opens the trabecular meshwork to facilitate aqueous humor outflow and rapidly reduce elevated intraocular pressure.
2.PRODUCT INDICATIONS
This product is clinically approved for two main patient populations: individuals with severe dry mouth resulting from salivary gland damage (including post-radiation xerostomia, Sjögren's syndrome, and drug-induced salivary hypofunction) and patients requiring management of glaucoma. For ophthalmic use, it is indicated in cases of acute and chronic angle-closure glaucoma, open-angle glaucoma, and is also utilized pre- and post-ocular surgery to achieve miosis. It is particularly suitable for adults and elderly patients who are experiencing significant discomfort from sicca symptoms or require immediate reduction of eye pressure.
3.CLINICAL EFFICACY OF PRODUCT
Clinical studies and real-world use have demonstrated that oral Pilocarpine Nitrate provides statistically significant improvement in salivary flow rates and subjective sensation of oral dryness compared to placebo or artificial saliva, with a substantial proportion of patients achieving meaningful symptomatic relief. In ophthalmology, its efficacy is evidenced by a marked reduction in intraocular pressure and the rapid resolution of acute angle-closure attacks. The therapeutic benefits are dose-dependent, with optimal results seen in patients adhering to a regular dosing schedule, although common cholinergic side effects like sweating and gastrointestinal discomfort are frequently observed but generally manageable.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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