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Chemicals
Tetracosactide Acetate CAS NO.16960-16-0/60189-34-6
<p>Tetracosactide Acetate, also known as Cosyntropin, is a high-purity synthetic peptide analog of Adrenocorticotropic Hormone (ACTH 1-24). It is widely utilized as a diagnostic reagent for assessing adrenal gland function, particularly in the detection of adrenal insufficiency. Beyond diagnostics, it is also applied in therapeutic settings for managing inflammatory and autoimmune conditions such as rheumatoid arthr…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Tetracosactide Acetate |
| CAS NO. | 16960-16-0/60189-34-6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C136H210N40O31S |
| Molecular Weight | 2933.39 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water and dilute acids; insoluble in organic solvents |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Potent synthetic ACTH analog; stimulates cortisol release from adrenal cortex |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Tetracosactide Acetate functions as a potent melanocortin-2 receptor (MC2R) agonist, binding to specific receptors on the adrenal cortex. This interaction triggers the activation of adenylate cyclase, leading to an increase in intracellular cAMP. The elevated cAMP levels subsequently stimulate the enzymatic conversion of cholesterol into glucocorticoids (primarily cortisol), mineralocorticoids, and weak androgens. It is designed to mimic the biological activity of natural ACTH while exhibiting reduced immunogenicity due to the absence of the antigenic C-terminal segment found in the full-length hormone.
2.PRODUCT INDICATIONS
This product is primarily indicated for diagnostic purposes, specifically in the ACTH stimulation test to evaluate adrenal皮质 function and differentiate between primary and secondary adrenal insufficiency. Therapeutically, it is used as an alternative to synthetic corticosteroids in the management of chronic inflammatory diseases, including rheumatoid arthritis, ulcerative colitis, and certain dermatological conditions. It is also indicated for preventing adrenal atrophy in patients undergoing long-term corticosteroid therapy and is being investigated for use in shock and idiopathic membranous nephropathy.
3.CLINICAL EFFICACY OF PRODUCT
Clinical studies have demonstrated that Tetracosactide Acetate reliably induces a rapid increase in plasma cortisol levels within 30 to 60 minutes post-administration, making it a gold standard for adrenal function testing. In therapeutic contexts, it has shown efficacy in reducing disease activity scores and inflammatory markers in patients with rheumatoid arthritis and inflammatory bowel disease. Its ability to stimulate endogenous cortisol production offers a physiological approach to immunosuppression, with a clinical profile characterized by potent steroidogenic effects and a lower incidence of allergic reactions compared to natural ACTH extracts.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
HotTags:Tetracosactide Acetate, Cosyntropin, ACTH 1-24, Adrenal Function Test, Adrenal Insufficiency, Synthetic Peptide, MC2R Agonist, Glucocorticoid, Diagnostic Reagent, Rheumatoid Arthritis, Inflammatory Bowel Disease, Research Peptide, Pharmaceutical API, Hormone Analog, Supplier, Manufacturer, Bulk order, Pharmaceutical.
If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553
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