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Chemicals
Distearoylphosphatidylserine CAS NO.51446-62-9
<p>Distearoylphosphatidylserine (DSPS) is a high-purity synthetic phospholipid featuring two saturated stearic acid chains (C18:0) and a negatively charged phosphatidylserine headgroup. As a key anionic excipient, it is primarily utilized in the formulation of liposomal drug delivery systems and artificial membrane models. Its saturated lipid structure provides superior thermal stability and membrane rigidity compar…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Distearoylphosphatidylserine |
| CAS NO. | 51446-62-9 |
| Appearance | White to off-white powder |
| Molecular Formula | C42H82NO10P |
| Molecular Weight | 792.07 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in chloroform, methanol, and polar organic solvents; insoluble in water |
| Endotoxin | ≤5 EU/mg |
| Biological Activity | Lipid component for stabilizing liposomes and facilitating cellular uptake |
| Storage Conditions | Store at 2–8°C in a dry, dark place, sealed tightly |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The functional mechanism of Distearoylphosphatidylserine centers on its role as a signaling lipid and a structural stabilizer. In biological contexts, the phosphatidylserine headgroup serves as a critical "eat-me" signal, which is externalized during apoptosis to facilitate phagocytic clearance; when incorporated into liposomes, it can mimic this signal for targeted immune interactions. Structurally, the saturated stearoyl chains confer a high phase transition temperature, resulting in a more rigid and less permeable bilayer that enhances nanoparticle stability in serum. The anionic charge of its headgroup also enables electrostatic complexation with cationic drugs or nucleic acids, improving loading capacity and modulating biodistribution by reducing non-specific protein adsorption.
2.PRODUCT INDICATIONS
Distearoylphosphatidylserine is indicated for use as a critical raw material in the development of advanced drug delivery platforms, including long-circulating liposomal formulations for anticancer and antifungal therapies. It is also widely employed in the design of gene delivery vectors where surface charge modulation is required for efficient complexation and cellular uptake. Additionally, due to its ability to mimic endogenous apoptotic signals, it finds significant application in immunological research and the development of vaccine adjuvants that require dendritic cell recognition. The product is tailored for pharmaceutical manufacturers, academic research institutions, and biotechnology companies focused on improving therapeutic efficacy through nanocarrier engineering.
3.CLINICAL EFFICACY OF PRODUCT
While Distearoylphosphatidylserine itself is a pharmaceutical intermediate rather than a finished drug, its efficacy is demonstrated through its contribution to the performance of liposomal formulations. Preclinical studies have shown that DSPS-containing liposomes exhibit enhanced stability and prolonged circulation half-life, which are critical for passive tumor targeting via the EPR effect. In experimental models, such carriers have demonstrated improved payload delivery to target tissues and reduced off-target toxicity. The presence of the phosphatidylserine motif has been associated with improved immune recognition in vaccine studies, suggesting a dual role in both drug delivery and immunomodulation, although clinical translation is still under active investigation.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553
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