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Chemicals
4-Methyl-2-oxopentanoic acid CAS NO.816-66-0
<p>4-Methyl-2-oxopentanoic acid, widely recognized in the market as α-Ketoisocaproic acid (KIC) or ketoleucine, is a pivotal endogenous metabolite derived from the transamination of the essential branched-chain amino acid L-Leucine. This high-purity alpha-keto acid serves as a direct precursor in leucine metabolism, strategically positioned to support energy production and nitrogen management. It is particularly val…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | 4-Methyl-2-oxopentanoic acid |
| CAS NO. | 816-66-0 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C6H10O3 |
| Molecular Weight | 130.14 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water; slightly soluble in ethanol; insoluble in non-polar solvents |
| Endotoxin | < 0.1 EU/mg |
| Biological Activity | Precursor to L-leucine; supports branched-chain amino acid metabolism and muscle protein synthesis |
| Storage Conditions | Store at 2–8°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The compound exerts its effects through a multi-faceted mechanism: it is rapidly converted back to L-Leucine in the body, thereby directly activating the mTOR signaling pathway to stimulate muscle protein synthesis. Concurrently, it exhibits anticatabolic properties by inhibiting the degradation of skeletal muscle proteins. At the metabolic level, it functions as an oxidative phosphorylation (OXPHOS) inhibitor and an uncoupler by targeting the alpha-ketoglutarate dehydrogenase complex (OGDC), which influences energy metabolism and mitochondrial function. This dual action of promoting synthesis while reducing breakdown makes it a potent modulator of net protein balance.
2.PRODUCT INDICATIONS
This product is primarily indicated for use in dietary supplements targeting muscle performance and recovery, appealing to athletes, bodybuilders, and individuals engaged in intensive training. Beyond sports nutrition, it holds significant relevance in clinical research applications, including metabolic disorder studies such as maple syrup urine disease (MSUD) due to its role in branched-chain amino acid metabolism. Additionally, its nitrogen-sparing properties make it a candidate for investigation in renal nutrition strategies, particularly in formulations aimed at managing muscle wasting associated with chronic kidney disease or acute renal dysfunction.
3.CLINICAL EFFICACY OF PRODUCT
Research and clinical observations have demonstrated that supplementation with 4-Methyl-2-oxopentanoic acid effectively elevates plasma leucine levels, which is directly correlated with enhanced rates of muscle protein synthesis. Studies indicate its efficacy in shifting the body from a catabolic to an anabolic state, thereby aiding in the preservation of lean body mass during periods of stress or caloric restriction. In athletic populations, it has been shown to accelerate post-exercise recovery and reduce markers of muscle damage. Its clinical utility is further supported by its role in improving nitrogen balance in patients with renal impairment, offering a therapeutic approach to combat muscle atrophy.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
HotTags:KIC, AlphaKetoisocaproate, LeucineMetabolite, MuscleRecovery, Anabolic, BCAAMetabolism, NitrogenSparing, BodybuildingSupplement, ResearchChemical, MetabolicHealth, Supplier, Manufacturer, Bulk order, Pharmaceutical.
If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553
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Global Technology Co., Ltd.
