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Chemicals
Abarelix Acetate CAS NO.183552-38-7
<p>Abarelix Acetate is a synthetic decapeptide and a potent gonadotropin-releasing hormone (GnRH) antagonist developed for the palliative treatment of advanced prostate cancer. Marketed under the brand name Plenaxis, it is provided as a sterile dry powder for injectable suspension, which is reconstituted for intramuscular administration. Unlike traditional agonists, this compound achieves rapid medical castration wi…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Abarelix Acetate |
| CAS NO. | 183552-38-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C72H95C1N14O14 |
| Molecular Weight | 1416.06 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water; reconstitutes to clear, colorless solution upon mixing |
| Endotoxin | ≤10 EU/mg (Limulus Amebocyte Lysate assay) |
| Biological Activity | Potent GnRH receptor antagonist; induces rapid testosterone suppression |
| Storage Conditions | Store at 2–8°C, protected from light; avoid freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Abarelix functions as a competitive antagonist at the GnRH receptors in the anterior pituitary gland. By blocking the binding of endogenous GnRH, it directly and rapidly inhibits the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This immediate suppression of the hypothalamic-pituitary-gonadal axis leads to a swift reduction in testicular testosterone production, achieving medical castration levels within days. This direct antagonistic action avoids the "testosterone flare" phenomenon associated with GnRH agonists, providing a safer profile for patients at risk of tumor-related complications from transient hormone surges.
2.PRODUCT INDICATIONS
Abarelix Acetate is indicated for the palliative treatment of men with advanced symptomatic prostate cancer who are not candidates for LHRH agonist therapy and have refused orchiectomy. This includes patients at high risk for tumor-related neurological sequelae, ureteral obstruction, or severe bone pain from metastases. It is specifically tailored for those requiring fast and sustained testosterone suppression without the initial agonist-induced flare, offering a crucial alternative for symptomatic relief and disease management in late-stage cancer care.
3.CLINICAL EFFICACY OF PRODUCT
Clinical trials demonstrated that Abarelix achieves and maintains medical castration levels of testosterone in over 95% of patients by day 29 of treatment. The drug provides a rapid reduction in serum testosterone, with 72% of patients reaching castration levels within one week and 98% by four weeks. This rapid action translates to significant palliative benefits, including relief of bone pain and reduction in the risk of spinal cord compression and urinary obstruction in advanced disease. Its efficacy is comparable to LHRH agonists but with the distinct advantage of avoiding the initial disease flare, making it particularly effective for symptomatic, advanced-stage patients.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
HotTags:AbarelixAcetate, Plenaxis, GnRHAntagonist, ProstateCancer, MedicalCastration, PeptideTherapeutics, HormoneTherapy, CancerResearch, OncologyDrug, PharmaPeptide, Supplier, Manufacturer, Bulk order, Pharmaceutical.
If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553
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