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Chemicals
Guvacoline hydrochloride CAS NO.6197-39-3
<p>Guvacoline hydrochloride, also known as Norarecoline hydrochloride, is a naturally occurring pyridine alkaloid originally isolated from the Areca nut (Areca triandra). It functions as a muscarinic acetylcholine receptor (mAChR) agonist, primarily utilized as a reference standard and research tool in neuropharmacology and toxicology studies to investigate cholinergic signaling pathways and receptor binding mechani…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Guvacoline Hydrochloride |
| CAS NO. | 6197-39-3 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C₇H₁₁NO₂·HCl |
| Molecular Weight | 191.63 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water, methanol, DMSO; slightly soluble in ethanol |
| Endotoxin | ≤10 EU/mg (LAL test) |
| Biological Activity | Potent muscarinic acetylcholine receptor agonist; IC₅₀ ~10–20 μM (at M₁/M₃ subtypes) |
| Storage Conditions | Store at 2–8°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Guvacoline hydrochloride acts as a full agonist at muscarinic acetylcholine receptors, specifically targeting atrial and ileal subtypes. It mimics the effects of acetylcholine by binding to G-protein coupled muscarinic receptors, thereby activating downstream signaling cascades that modulate smooth muscle contraction, glandular secretion, and neuronal excitability, although with approximately 15-fold lower potency compared to its analog Arecoline.
2.PRODUCT INDICATIONS
This compound is indicated for research applications in cardiovascular and gastrointestinal pharmacology, serving as a critical tool for studying mAChR function in vitro and in vivo. It is also used in toxicology research related to Areca nut consumption, metabolism studies, and as a chemical intermediate for synthesizing related alkaloid derivatives in academic and pharmaceutical R&D settings
3.CLINICAL EFFICACY OF PRODUCT
While Guvacoline hydrochloride itself is not approved for clinical use, preclinical studies demonstrate its efficacy in eliciting characteristic muscarinic responses such as ileal smooth muscle contraction and atrial bradycardia. Research-grade data confirms its bioactivity as a cholinergic agonist, providing foundational insights for understanding the pharmacological and toxicological profiles of Areca nut alkaloids.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: GuvacolineHydrochloride #CAS6197393 #Norarecoline #MuscarinicAgonist #ArecaAlkaloid #CholinergicResearch #ResearchChemical #PharmaceuticalIntermediate
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