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Chemicals
Camptothecine CAS NO.7689-03-4
<p>Camptothecine is a naturally occurring quinoline alkaloid derived from the Chinese tree <em>Camptotheca acuminata</em>. It serves as the pharmacophore for several FDA-approved chemotherapeutic agents, including irinotecan and topotecan. Its primary mechanism involves irreversible inhibition of topoisomerase I, an enzyme critical for DNA replication and transcription, leading to stalled replication forks, double-s…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Camptothecine |
| CAS NO. | 7689-03-4 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C₂₀H₁₆N₂O₄ |
| Molecular Weight | 348.35 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in organic solvents (e.g., DMSO, chloroform); poorly soluble in water |
| Endotoxin | ≤ 50 EU/mg (for cell culture and in vitro use; may differ by batch) |
| Biological Activity | Potent topoisomerase I inhibitor; induces DNA damage and apoptosis in cancer cells; exhibits broad anti-tumor activity against various solid and hematologic malignancies |
| Storage Conditions | Lyophilized powder: Store at 2–8°C in a dry, dark place; stable for 24–36 months. Reconstituted solutions: Store at -20°C, protected from light, and use within 1–2 weeks; avoid freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Camptothecine exerts its antitumor effect by selectively inhibiting topoisomerase I, an essential nuclear enzyme that relieves torsional stress during DNA replication and transcription by transiently cleaving and religating single-stranded DNA. By stabilizing the covalent enzyme-DNA cleavage complex, camptothecine prevents re-ligation, resulting in persistent DNA strand breaks that trigger cell cycle arrest (primarily at G2/M phase) and activate apoptotic pathways via p53-dependent and independent mechanisms. This mechanism is particularly effective in rapidly proliferating cancer cells, which are more reliant on topoisomerase I activity for survival, thereby conferring selective cytotoxicity against malignant tissues while minimizing damage to quiescent normal cells.
2.PRODUCT INDICATIONS
Camptothecine is primarily indicated for use in preclinical research settings to investigate novel anticancer therapies, evaluate tumor cell sensitivity, and explore mechanisms of drug resistance. It is suitable for in vitro studies using human and murine cancer cell lines, in vivo xenograft models, and pharmacokinetic/pharmacodynamic analyses. Additionally, it serves as a key intermediate for the synthesis of clinically approved derivatives such as irinotecan (for colorectal cancer) and topotecan (for ovarian and small cell lung cancer). Researchers in oncology, molecular biology, and medicinal chemistry leverage camptothecine to advance understanding of DNA damage repair, apoptosis signaling, and targeted cancer therapy development.
3.CLINICAL EFFICACY OF PRODUCT
Although camptothecine itself is not used clinically due to its poor solubility and toxicity profile, its structural derivatives—irinotecan and topotecanhave demonstrated— significant clinical efficacy in treating metastatic colorectal cancer, ovarian cancer, and small cell lung cancer. Clinical trials have shown that these derivatives improve overall survival and progression-free survival compared to traditional chemotherapy regimens. The parent compound remains invaluable in research for optimizing delivery systems, improving bioavailability, and designing next-generation analogs with enhanced therapeutic indices. Its role in advancing precision oncology and personalized medicine continues to drive innovation in cancer therapeutics.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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