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Chemicals
AST2818mesylate CAS NO.2130958-55-1
<p>AST2818 mesylate, also known as Alflutinib or Furmonertinib, is a highly selective third-generation EGFR tyrosine kinase inhibitor (TKI) developed for the targeted treatment of non-small cell lung cancer (NSCLC). It is specifically engineered to potently inhibit EGFR sensitizing mutations (such as exon 19 deletions and L858R) as well as the resistant T790M mutation, while exhibiting minimal off-target effects on …
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | AST2818mesylate |
| CAS NO. | 2130958-55-1 |
| Appearance | White to off-white powder |
| Molecular Formula | C29H35F3N8O5S |
| Molecular Weight | 688.77 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in DMSO, methanol, water (pH-dependent); slightly soluble in ethanol |
| Endotoxin | ≤5 EU/mg (LAL test) |
| Biological Activity | Potent, irreversible EGFR inhibitor; IC₅₀ for EGFR L858R/T790M < 1 nM |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The compound functions as an irreversible inhibitor that covalently binds to the cysteine-797 residue in the ATP-binding site of mutant EGFR kinases. By selectively blocking the signaling pathways of mutant EGFR variants (including T790M), it effectively suppresses tumor cell proliferation and survival, with reduced activity against wild-type EGFR to minimize skin and gastrointestinal toxicities commonly associated with earlier generation TKIs.
2.PRODUCT INDICATIONS
AST2818 mesylate is indicated for the treatment of adult patients with locally advanced or metastatic NSCLC harboring EGFR T790M mutation, particularly following progression on prior EGFR-TKI therapy. It is also applicable for first-line treatment of EGFR mutation-positive advanced NSCLC, targeting individuals who require a potent and well-tolerated oral targeted therapy option.
3.CLINICAL EFFICACY OF PRODUCT
Clinical trials, including the pivotal Phase III FURLONG study, have demonstrated that AST2818 mesylate achieves high objective response rates (ORR) and significantly prolongs progression-free survival (PFS) in patients with EGFR T790M-positive NSCLC. The drug shows robust efficacy in controlling central nervous system (CNS) metastases and maintains a manageable safety profile with a low incidence of severe adverse events.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: AST2818mesylate #CAS2130958551 #Furmonertinib #Alflutinib #EGFRT790M #ThirdGenerationEGFRTKI #NSCLCTargetedTherapy #EGFRMutation
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