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Chemicals
Dermorphin CAS NO.77614-16-5
<p>Dermorphin is a synthetic heptapeptide derived from the skin of the South American frog <em>Phyllomedusa sauvagii</em>, prized for its extraordinary potency as a μ-opioid receptor agonist and its ability to penetrate the blood-brain barrier efficiently. It is extensively used in neuroscience and pharmacology research to explore pain modulation, reward circuits, and opioid tolerance mechanisms. Its unique structur…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Dermorphin |
| CAS NO. | 77614-16-5 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₄₀H₅₀N₈O₁₀ |
| Molecular Weight | 802.88g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water, dilute acids, and DMSO; partially soluble in methanol; insoluble in non-polar solvents (e.g., hexane, ether) |
| Endotoxin | ≤ 0.1 EU/mg (for research-grade materials; subject to batch-specific Certificate of Analysis) |
| Biological Activity | Potent μ-opioid receptor agonist with high analgesic potency; exhibits prolonged activity compared to morphine; used to study pain pathways, opioid receptor pharmacology, and addiction mechanisms |
| Storage Conditions | Lyophilized powder: Store at 2–8°C in a dry, dark place; stable for 24–36 months. Reconstituted solutions: Store at -20°C, protected from light, and use within 1–2 weeks; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Dermorphin exerts its powerful analgesic effect by selectively and potently binding to and activating μ-opioid receptors in the central nervous system, inhibiting the release of nociceptive neurotransmitters such as substance P and glutamate. Its D-amino acid configuration enhances resistance to enzymatic degradation, allowing prolonged receptor engagement and sustained analgesia. This mechanism also triggers downstream signaling cascades involving G-proteins, adenylate cyclase inhibition, and potassium channel activation, leading to neuronal hyperpolarization and reduced pain perception.
2.PRODUCT INDICATIONS
Dermorphin is indicated exclusively for in vitro and in vivo research applications, including studies on chronic pain models, opioid addiction, neuroprotection, and the development of novel analgesics. It is also used in preclinical pharmacokinetic and pharmacodynamic evaluations, particularly for assessing receptor selectivity and cross-tolerance with other opioid ligands. Researchers in academia, pharmaceutical R&D, and contract research organizations rely on Dermorphin for mechanistic investigations and drug discovery platforms targeting the opioid system.
3.CLINICAL EFFICACY OF PRODUCT
While Dermorphin has not been approved for clinical human use due to its extreme potency and risk of dependence, its efficacy in animal models is well-documented — producing profound analgesia with doses significantly lower than morphine. In rodent and primate studies, it demonstrates superior duration of action and potency, often requiring microgram or even nanogram doses for significant effect. These findings support its value as a benchmark compound for evaluating new opioid drugs and understanding the limits of receptor-mediated pain control.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157
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