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Chemicals
Ganoderic acid A CAS NO.81907-62-2
<p>Ganoderic Acid A (GAA, CAS 81907-62-2) is a high-purity, oxygenated lanostane-type triterpenoid and a principal bioactive compound isolated from the medicinal mushroom <em>Ganoderma lucidum</em>(Lingzhi or Reishi). It serves as a key marker for the quality assessment of Reishi extracts. Renowned for its diverse pharmacological activities, Ganoderic Acid A is extensively researched for its significant anti-cancer,…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Ganoderic Acid A |
| CAS NO. | 81907-62-2 |
| Appearance | White to off-white powder |
| Molecular Formula | C₃₀H₄₂O₇ |
| Molecular Weight | 514.65 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in methanol, ethanol, DMSO, DMF; slightly soluble in chloroform; practically insoluble in water |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Natural lanostane-type triterpenoid from Ganoderma lucidum; exhibits hepatoprotective, anti-tumor, anti-inflammatory, antioxidant and immunomodulatory activities |
| Storage Conditions | Store at 2–8 °C in a tightly sealed container, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Ganoderic Acid A exerts its effects through the targeted modulation of multiple cellular signaling pathways. Its antitumor action involves the induction of cell cycle arrest (G1/S phase) and apoptosis via the mitochondrial pathway, characterized by caspase-3 activation, PARP cleavage, and modulation of Bcl-2 family proteins. It inhibits cancer cell migration and invasion by downregulating matrix metalloproteinases (MMPs). Furthermore, it demonstrates potent anti-inflammatory activity by suppressing NF-κB and AP-1 signaling, leading to reduced production of pro-inflammatory cytokines (TNF-α, IL-6, COX-2). It also acts as a natural inhibitor of HIV-1 protease.
2.PRODUCT INDICATIONS
Oncology Research: Investigation of antiproliferative, pro-apoptotic, and anti-metastatic mechanisms in liver, lung, breast, and prostate cancer models.
- Hepatology Studies: Exploration of hepatoprotective effects against toxin-induced (e.g., alcohol, acetaminophen) liver injury and fibrosis.
- Anti-inflammatory & Immunomodulation: Research on inflammatory diseases such as arthritis and colitis.
Pharmaceutical QC: Certified reference standard for authentication, standardization, and quality control of Ganoderma lucidumextracts and related nutraceuticals.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
3.CLINICAL EFFICACY OF PRODUCT
While direct human clinical trials on isolated Ganoderic Acid A are limited, its efficacy is strongly supported by extensive preclinical data. In vitro and in vivo studies demonstrate potent cytotoxicity against a wide range of cancer cell lines, inhibition of tumor growth in xenograft models, and significant protection against chemical-induced hepatotoxicity. The clinical use of whole Ganodermaextracts, for which GAA is a major active constituent, is associated with improved immune function and reduced side effects in cancer patients, providing translational relevance. Its multi-target bioactivity underscores its therapeutic promise.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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