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Chemicals
AN 2728 CAS NO.906673-24-3
<p>AN 2728 (Crisaborole) is a novel, small-molecule benzoxaborole-class drug substance renowned for its topical anti-inflammatory efficacy and non-steroidal mechanism. It is primarily utilized as a high-value active pharmaceutical ingredient (API) in the formulation of dermatological ointments and creams targeting chronic skin inflammation. With excellent skin permeability and a favorable safety profile, this boron-…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | AN 2728 |
| CAS NO. | 906673-24-3 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C14H10BNO3 |
| Molecular Weight | 254.05 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in DMSO, methanol, ethanol; sparingly soluble in water |
| Endotoxin | ≤ 0.5 EU/mg |
| Biological Activity | Potent and selective phosphodiesterase-4 (PDE4) inhibitor |
| Storage Conditions | Store at 2–8°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
AN 2728 functions as a potent and selective phosphodiesterase-4 (PDE4) inhibitor, targeting the enzyme's catalytic site via its unique boron-based structure. By blocking PDE4-mediated hydrolysis of cyclic AMP (cAMP), it elevates intracellular cAMP levels in immune cells, which in turn suppresses the transcription and release of key pro-inflammatory cytokines such as TNF-α, IL-6, IL-12, and IL-23. This upstream modulation of the inflammatory cascade effectively reduces T-cell activation and neutrophil infiltration, addressing the underlying immune dysregulation in skin disorders without the side effects associated with systemic corticosteroids.
2.PRODUCT INDICATIONS
This compound is specifically indicated for the development of topical therapeutics for mild to moderate atopic dermatitis (eczema) in patients aged two years and older, as well as for psoriasis vulgaris. It serves as the critical raw material for compounding pharmacies and pharmaceutical companies formulating non-steroidal, non-calcineurin inhibitor alternatives. Additionally, research-grade AN 2728 is used in preclinical studies investigating PDE4-driven inflammatory pathways and for the development of novel topical solutions for allergic contact dermatitis and other immune-mediated skin conditions.
3.CLINICAL EFFICACY OF PRODUCT
Clinical studies demonstrate that Felypressin significantly prolongs the anesthetic effect and reduces intraoperative bleeding, with a duration of action comparable to epinephrine-containing formulations but with a markedly reduced impact on heart rate and blood pressure. Its efficacy is well-established in patients with cardiovascular risk factors, where it provides stable hemodynamic conditions during dental treatment. Research confirms its ability to deliver adequate anesthesia and hemostasis while minimizing adverse systemic effects, ensuring patient safety and procedural success.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: AN2728 #Crisaborole #CAS9066732443 #PDE4Inhibitor #Benzoxaborole #TopicalAntiInflammatory #AtopicDermatitisAPI #Eucrisa #NonSteroidal #SkinInflammation #PharmaceuticalIntermediate #BoronChemistry #ResearchChemical
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