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Chemicals
Enfuvirtide Acetate CAS NO.159519-65-0
<p>Enfuvirtide Acetate is a synthetic 36-amino acid peptide salt form of the first-in-class HIV fusion inhibitor, widely utilized as a critical active pharmaceutical ingredient (API) in antiretroviral therapy. Originally approved by the FDA in 2003 under the brand name Fuzeon, this acetate formulation enhances the stability and solubility profile of the peptide, making it suitable for pharmaceutical manufacturing an…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Enfuvirtide Acetate |
| CAS NO. | 159519-65-0 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C204H301N51O64 |
| Molecular Weight | 4492.01 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water; slightly soluble in acidic solutions; insoluble in organic solvents |
| Endotoxin | ≤5 EU/mg |
| Biological Activity | Inhibits HIV-1 entry into CD4+ T cells via gp41-mediated fusion blockade |
| Storage Conditions | Store at 2–8°C, protected from light and moisture; stable for 24 months |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Enfuvirtide Acetate functions as an HIV-1 fusion inhibitor by precisely targeting the viral envelope glycoprotein gp41. It acts as a biomimetic decoy that mimics the HR2 domain of gp41, competitively binding to the HR1 region on the virus. This high-affinity binding sterically hinders the formation of the six-helix bundle structure required for the fusion of the viral membrane with the host CD4+ cell membrane. By blocking this crucial conformational change, the peptide effectively prevents viral entry into human cells, halting the infection cycle at its earliest stage without affecting intracellular processes.
2.PRODUCT INDICATIONS
This product is indicated for the treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection in combination with other antiretroviral agents. It is primarily reserved for treatment-experienced adults and pediatric patients (aged 6 years and above) who exhibit evidence of ongoing viral replication despite extensive therapy, and who harbor HIV-1 strains resistant to multiple drug classes. Enfuvirtide Acetate serves as a vital salvage therapy component for managing multidrug-resistant HIV, providing a new therapeutic option for populations with limited treatment alternatives due to resistance or intolerance issues.
3.CLINICAL EFFICACY OF PRODUCT
Clinical trials, including the pivotal TORO studies, have demonstrated that subcutaneous Enfuvirtide significantly increases CD4 cell counts and reduces viral load when added to an optimized background regimen in heavily pretreated patients. Over 48 weeks of treatment, the addition of Enfuvirtide resulted in a significantly higher proportion of patients achieving undetectable viral loads compared to optimized therapy alone. Its unique extracellular mechanism ensures no cross-resistance with existing drug classes, making it highly effective against resistant strains and establishing it as a cornerstone of rescue therapy for advanced HIV disease.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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