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Chemicals
Guggulsterone E CAS NO.39025-24-6
<p>Guggulsterone E is a bioactive phytosterol derived from the Commiphora wightii plant, traditionally used in Ayurvedic medicine. It is widely utilized in research for its potent hypolipidemic, anti-inflammatory, and antioxidant properties. This natural compound is particularly valued for its role in metabolic and cardiovascular research, offering a plant-based approach to studying cholesterol regulation and inflam…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Guggulsterone E |
| CAS NO. | 39025-24-6 |
| Appearance | Off-white to light yellow crystalline powder |
| Molecular Formula | C₂₁H₂₈O₂ |
| Molecular Weight | 312.45 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in DMSO, methanol, ethanol; slightly soluble in water |
| Endotoxin | < 0.1 EU/mg (for research grade) |
| Biological Activity | Modulates cholesterol metabolism, exhibits anti-inflammatory and lipid-lowering properties; potential TGR5 receptor agonist activity |
| Storage Conditions | Store at 2–8°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Guggulsterone E functions primarily as a farnesoid X receptor (FXR) antagonist, modulating bile acid and cholesterol metabolism. By blocking FXR activation, it alters the expression of genes involved in lipid homeostasis, leading to reduced cholesterol synthesis and increased clearance. Additionally, it inhibits NF-κB signaling, which suppresses pro-inflammatory cytokine production, and modulates other nuclear receptors like PPARγ and LXR, contributing to its broad metabolic and anti-inflammatory effects.
2.PRODUCT INDICATIONS
This product is indicated for research applications in hyperlipidemia, obesity, and metabolic syndrome. It is also used in studies related to atherosclerosis, due to its lipid-lowering and anti-inflammatory effects, as well as in oncology research for its potential to induce apoptosis and inhibit tumor cell proliferation. Researchers in pharmacology, nutraceuticals, and natural product development utilize it to investigate alternative therapies for cardiovascular and metabolic disorders.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical and clinical studies have demonstrated that Guggulsterone E significantly reduces serum levels of total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol. Its anti-inflammatory properties have shown efficacy in reducing markers of inflammation and oxidative stress. Although primarily used in research settings, it has shown promise in improving lipid profiles and metabolic parameters in animal models and human trials, supporting its potential as a natural therapeutic agent.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: GuggulsteroneE #FXRantagonist #Hypolipidemic #AntiInflammatory #MetabolicSyndrome #NaturalProduct #Commiphora #CholesterolResearch
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