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Chemicals
LMK-235 CAS NO.1418033-25-6
<p>LMK-235 is a potent and highly selective small-molecule inhibitor primarily targeting Class IIa Histone Deacetylases (HDAC4 and HDAC5). It is widely utilized in epigenetic research and preclinical studies for its ability to modulate gene expression and induce apoptosis in various cancer models. This research-grade compound is characterized by its nanomolar inhibitory activity and is commonly applied in investigat…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | LMK-235 |
| CAS NO. | 1418033-25-6 |
| Appearance | White to off-white powder |
| Molecular Formula | C₁₅H₂₂N₂O₄ |
| Molecular Weight | 294.35 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in DMSO; sparingly soluble in ethanol; insoluble in water |
| Endotoxin | ≤10 EU/mg (LAL test) |
| Biological Activity | Potent, selective inhibitor of LSD1 (Lysine-Specific Demethylase 1); modulates histone methylation and gene expression |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
LMK-235 functions as a selective epigenetic modulator by specifically inhibiting HDAC4 and HDAC5, which are key enzymes responsible for removing acetyl groups from histones. This inhibition leads to hyperacetylation of histones and non-histone proteins, resulting in a more relaxed chromatin structure and altered transcription of genes involved in cell cycle arrest and apoptosis. Its mechanism also involves downstream modulation of pathways such as JNK/AP-1 and Smad2/3, contributing to its anti-fibrotic and anti-inflammatory effects observed in cellular models.
2.PRODUCT INDICATIONS
This product is indicated for research applications focused on oncology, neurology, and cardiovascular biology. It is particularly relevant for scientists studying chemoresistant cancers (e.g., ovarian, breast, multiple myeloma), cardiac remodeling post-myocardial infarction, and neurological disorders such as CDKL5 deficiency disorder. LMK-235 serves as a critical tool compound for academic researchers and pharmaceutical R&D teams exploring novel HDAC inhibitor therapies and epigenetic mechanisms of disease.
3.CLINICAL EFFICACY OF PRODUCT
In preclinical studies, LMK-235 has demonstrated significant efficacy in reducing tumor cell viability and overcoming chemoresistance. Data from in vitro and in vivo models show that it effectively inhibits cancer cell proliferation, promotes apoptosis, and can restore neuronal health in neurological disease models. While currently classified as a research chemical and not yet approved for human use, its robust activity profile supports its strong potential as a lead candidate for future therapeutic development in targeted epigenetic interventions.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: LMK235 #HDAC4 #HDAC5 #Epigenetics #CancerResearch #HDACInhibitor #ResearchChemical #DrugDiscovery
If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85296236544
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Global Technology Co., Ltd.
