Image not available
Chemicals
DL-Kawain/dl-Kavain CAS NO. 3155-48-4
<p>DL-Kavain (also known as DL-Kawain) is one of the major bioactive kavalactones naturally found in Kava Kava (Piper methysticum). It is a well-researched phytochemical widely used as a reference standard and active ingredient in the development of nutraceuticals and herbal medicinal products. This compound is primarily recognized for its significant anxiolytic (anti-anxiety), sedative, and muscle-relaxant properti…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
Source categories
About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | DL-Kawain/dl-Kavain |
| CAS NO. | 3155-48-4 |
| Appearance | White to off - white crystalline powder |
| Molecular Formula | C₁₄H₁₄O₃ |
| Molecular Weight | 230.26 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in DMSO, methanol; slightly soluble in ethanol; insoluble in water |
| Endotoxin | ≤5 EU/mg (for high - purity grades used in biological/pharmaceutical research) |
| Biological Activity | Anxiolytic, sedative, muscle relaxant, anticonvulsant (via modulation of GABAₐ receptors and ion channels) |
| Storage Conditions | Store at 2 - 8°C in a dry, dark place; avoid light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
DL-Kavain modulates the central nervous system through a multi-target mechanism that does not involve the classic benzodiazepine binding site. It functions as a positive allosteric modulator of GABA_A receptors (particularly α4β2δ subtypes), enhancing inhibitory neurotransmission. Concurrently, it inhibits voltage-gated sodium and calcium channels, reducing neuronal excitability and contributing to its anticonvulsant and calming effects. Additional mechanisms include weak inhibition of monoamine oxidases (MAO-A/B) and norepinephrine reuptake, which collectively underpin its anxiolytic profile without the dependency risks associated with traditional benzodiazepines.
2.PRODUCT INDICATIONS
This product is indicated for research and development in formulations aimed at managing generalized anxiety disorder (GAD), stress-induced insomnia, and sleep disturbances. It is also relevant for studies on local analgesia, muscle relaxation, and neuroprotection. The primary target users include pharmaceutical R&D teams, nutraceutical companies developing natural anxiolytics, and academic researchers investigating GABAergic herbal extracts as alternatives to synthetic sedatives.
3.CLINICAL EFFICACY OF PRODUCT
Clinical and preclinical studies demonstrate that DL-Kavain significantly reduces anxiety scores, shortens sleep latency, and increases deep sleep (delta wave) activity. In comparative trials, kava extracts standardized for kavain content have shown efficacy comparable to low-dose benzodiazepines like oxazepam in alleviating anxiety, but with a more favorable safety profile regarding cognitive impairment and dependency. EEG studies confirm its ability to induce relaxation and improve sleep architecture, supporting its use as a non-addictive anxiolytic agent.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: DLKavain #Kavain #Kavalactone #KavaExtract #Anxiolytic #NaturalRelaxant #GABAmodulator #Neuropharmacology
If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85244219157
More from this supplier
Global Technology Co., Ltd.
