Alantolactone  CAS NO.546-43-0

TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

Alantolactone exerts its effects through multiple signaling pathways. Its α-methylene-γ-lactone group acts as a Michael acceptor, enabling it to alkylate cysteine residues on target proteins. This mechanism underlies its potent inhibition of STAT3 phosphorylation and nuclear translocation, disrupting cancer cell proliferation and survival. Additionally, it modulates the NF-κB and MAPK pathways to reduce pro-inflammatory cytokine production (TNF-α, IL-6), induces mitochondrial-dependent apoptosis via ROS generation and caspase-3 activation, and activates the Nrf2 pathway for antioxidant defense.

2.PRODUCT INDICATIONS

• Oncology Research: Investigation of STAT3-driven tumor models (breast, colon, glioblastoma) and chemoprevention studies.

• Anti-inflammatory & Immunomodulation: Study of rheumatoid arthritis, colitis, and macrophage polarization.

• Antimicrobial Screening: Evaluation against fungi, bacteria, and parasites.

• Pharmaceutical QC: Reference standard for authentication of Inulaextracts and herbal medicine quality control.

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• 3.CLINICAL EFFICACY OF PRODUCT

Preclinical data strongly supports the therapeutic potential of Alantolactone. In vivo studies demonstrate significant tumor growth inhibition in xenograft models with good tolerability. It effectively attenuates symptoms in rheumatoid arthritis and colitis models by reducing inflammatory infiltrates and cytokine storms. While human clinical trials are still limited, its efficacy as a multi-target agent against aggressive cancers and chronic inflammatory diseases makes it a promising candidate for drug development.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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