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Chemicals
Obacunone CAS NO. 751-03-1
<p>Obacunone is a highly oxidized, natural limonoid triterpenoid primarily derived from citrus fruits and the root bark of Dictamnus dasycarpus. Renowned for its broad-spectrum bioactivity, it serves as a key reference standard and active pharmaceutical ingredient (API) intermediate for researchers investigating natural product-based therapies. Its primary appeal lies in its potent anti-inflammatory and anticancer p…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Obacunone |
| CAS NO. | 751-03-1 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C₂₆H₃₀O₇ |
| Molecular Weight | 454.51 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in organic solvents (e.g., ethanol, DMSO); sparingly soluble in water |
| Endotoxin | ≤0.5 EU/mg (for biological applications) |
| Biological Activity | Exhibits anti-inflammatory, antioxidant, and potential anti-cancer activities; modulates signaling pathways (e.g., NF-κB, Nrf2) |
| Storage Conditions | Store at 2–8°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Obacunone exerts its effects through multiple signaling pathways. It functions as a histone deacetylase 1 (HDAC1) inhibitor and modulates key regulators such as NF-κB, STAT3, and the TLR4 axis to suppress pro-inflammatory cytokine production. Additionally, it induces mitochondrial-mediated apoptosis in cancer cells via caspase-3 activation and cytochrome c release, while also reducing oxidative stress by scavenging reactive oxygen species (ROS) and upregulating antioxidant defenses.
2.PRODUCT INDICATIONS
This compound is indicated for preclinical research in oncology (particularly colorectal, prostate, and liver cancers), inflammatory bowel disease (IBD) models, and metabolic disorders like type 2 diabetes. It is also relevant for studies on osteoarthritis, polycystic ovary syndrome (PCOS), and organ protection (e.g., liver, lung fibrosis). The target audience includes medicinal chemists, pharmacologists, and academic researchers focused on developing nutraceuticals or novel small-molecule therapeutics from plant sources.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical data demonstrates that Obacunone significantly reduces tumor incidence and volume in colitis-associated colorectal cancer models, improves insulin sensitivity in diabetic mice, and alleviates joint damage in osteoarthritis rats by preserving cartilage matrix. In toxicity studies, it shows a favorable safety profile with low acute toxicity, supporting its potential as a lead compound for clinical translation in chronic inflammatory and hyperproliferative diseases.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Obacunone #Limonoid #CitrusTriterpenoid #HDAC1Inhibitor #AntiCancer #AntiInflammatory #NaturalProductResearch #DrugDiscovery
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Global Technology Co., Ltd.
