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Chemicals
3′-Deoxyinosine CAS NO.13146-72-0
<p>3'-Deoxyinosine (also known as Didanosine EP Impurity D) is a high-purity purine nucleoside analog where the 3'-hydroxyl group of the ribose moiety is replaced by hydrogen. This structural modification classifies it as a key intermediate in nucleoside chemistry and a metabolite of cordycepin (3'-deoxyadenosine). It is widely utilized in biochemical research as a reference standard, a tool for studying…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | 3'-Deoxyinosine |
| CAS NO. | 13146-72-0 |
| Appearance | White to off-white solid/powder |
| Molecular Formula | C₁₀H₁₂N₄O₄ |
| Molecular Weight | 252.23 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Sparingly soluble in water, DMSO, and methanol; soluble in DMF/ethanol |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Purine nucleoside analog; inhibits DNA synthesis, induces apoptosis in indolent lymphoid malignancies; anti-leishmanial activity reported |
| Storage Conditions | -20°C (long-term) / 2–8°C (short-term), under inert atmosphere, sealed, dry, protected from light |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
As a nucleoside analog, 3'-Deoxyinosine primarily functions as a chain terminator and metabolic disruptor. It is intracellularly phosphorylated to its triphosphate form, which then competes with natural nucleotides for incorporation into growing DNA strands. The absence of the 3'-OH group prevents the formation of the phosphodiester bond, halting DNA elongation and leading to chain termination. This action inhibits DNA polymerase activity, disrupts nucleic acid synthesis, and induces apoptosis in rapidly dividing cells, such as cancer cells or parasites.
2.PRODUCT INDICATIONS
This product is strictly for research use (RUO) and is indicated for:
- Pharmaceutical QC: Serving as a certified reference standard (CRS) for Didanosine-related impurity analysis and method validation.
- Metabolic Research: Studying the pharmacokinetics and metabolic pathways of cordycepin and related nucleoside drugs.
- Antiparasitic Screening: In vitro evaluation against Trypanosoma cruziand Leishmaniaspecies.
- Biochemical Tool: Investigating nucleotide metabolism, DNA repair mechanisms, and nucleoside transport systems.
3.CLINICAL EFFICACY OF PRODUCT
While 3'-Deoxyinosine itself is not a clinically approved drug, its efficacy is demonstrated in preclinical research. Studies show it exhibits growth-inhibitory effects on trypanosomes and leishmania in vitro. As the primary metabolite of cordycepin, it contributes to the overall pharmacokinetic profile and biological activity observed in vivo. Data supports its role as a bioactive molecule with potential implications for developing treatments for neglected tropical diseases and as a marker for nucleoside drug metabolism.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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If you have any product requirements, please send an email to:business@huanqiukeji9.com;whatsapp:852 7084 6510
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