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Chemicals
Chrysosplenol D CAS NO.14965-20-9
<p>Chrysosplenol D is a high-purity natural methoxyflavonol compound extracted from <em>Artemisia annua</em>L., widely used as a reference standard and active ingredient in pharmacological research. It is characterized by its multi-target biological activity, primarily focusing on anti-tumor and anti-inflammatory applications. This product is supplied as a stable yellow powder with purity typically ≥98% (HPLC-verifi…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Chrysosplenol D |
| CAS NO. | 14965-20-9 |
| Appearance | Yellow to orange powder |
| Molecular Formula | C18H16O8 |
| Molecular Weight | 360.30 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in DMSO, methanol; sparingly soluble in water, ethanol |
| Endotoxin | < 0.1 EU/mg |
| Biological Activity | Exhibits antioxidant, anti-inflammatory, and anti-tumor activities via modulation of NF-κB, MAPK, and PI3K/AKT pathways |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Chrysosplenol D exerts its effects by modulating the TLR4-MAPKs/NF-κB signaling pathway, effectively inhibiting the release of pro-inflammatory cytokines (IL-6, TNF-α, IL-1β) and oxidative stress. In cancer research, it selectively induces apoptosis in tumor cells by activating ERK1/2 and increasing intracellular reactive oxygen species (ROS), leading to mitochondrial membrane potential loss and autophagy. It also demonstrates moderate antitrypanosomal activity and can act as an efflux pump inhibitor to enhance the efficacy of antibiotics.
2.PRODUCT INDICATIONS
This product is indicated for scientific research in oncology, particularly for studying triple-negative breast cancer (TNBC), prostate cancer, and oral squamous cell carcinoma. It is also applicable in inflammation and immunology models, such as LPS-induced acute lung injury, systemic inflammatory response syndrome (SIRS), and croton oil-induced ear edema. Additionally, it serves as a tool compound for investigating Nrf2/HO-1 antioxidant pathways and antimicrobial adjuvant therapy.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical studies confirm that Chrysosplenol D significantly inhibits the viability of MDA-MB-231, PC-3, and A549 cancer cell lines, with in vivo data showing tumor growth suppression on chick chorioallantoic membranes. In inflammatory models, it protects against LPS-induced lung injury and SIRS by reducing inflammatory infiltration and regulating immune cell apoptosis. While current evidence is robust in animal and cell studies, its clinical translation remains under investigation, highlighting its primary value as a potent research-grade bioactive agent.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags:Chrysosplenol D, Flavonol, Natural Product, Apoptosis, Anti-inflammatory, Antioxidant, Artemisia annua, Methoxyflavone, Cancer Research, NF-κB, ERK1/2, ROS, HO-1, Biochemical Reagent, Reference Standard, Supplier, Manufacturer, Bulk order, Pharmaceutical.
If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553
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