Astragaloside III CAS NO.84687-42-3

<p>Astragaloside III is a triterpenoid saponin and a principal bioactive constituent isolated from the roots of <em>Astragalus membranaceus</em>(Huangqi), a fundamental herb in Traditional Chinese Medicine. It belongs to the astragaloside family, which is renowned for its immunomodulatory, anti-aging, and cardioprotective properties. Astragaloside III is specifically recognized for its potent biological activities, …

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Astragaloside III
CAS NO.	84687-42-3
Appearance	White to off-white fine powder
Molecular Formula	C₄₁H₆₈O₁₄
Molecular Weight	784.97 g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in methanol, ethanol, DMSO; sparingly soluble in water; insoluble in petroleum ether
Endotoxin	<0.05 EU/mg
Biological Activity	- Anti-inflammatory and immunomodulatory effects - Cardioprotective activity - Neuroprotective potential - Antioxidant properties
Storage Conditions	S-20°C (long-term, sealed, dry, protected from light); 2-8°C (short-term storage ≤3 months)
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Astragaloside III exerts its effects through multiple molecular pathways. A primary mechanism involves the activation of the PI3K/Akt signaling pathway, which promotes cell survival and inhibits apoptosis. It also modulates immune function by regulating the activity of T-cells and macrophages, and enhancing the production of antibodies. Furthermore, it demonstrates strong anti-inflammatory activity by downregulating NF-κB and MAPK pathways, reducing the expression of pro-inflammatory cytokines. Its antioxidant action is linked to the upregulation of the Nrf2/HO-1 pathway, mitigating oxidative stress.

2.PRODUCT INDICATIONS

Astragaloside III is indicated for use in advanced pharmacological research and as a high-purity reference standard for the quality control of Astragalus membranaceusextracts. Its research applications focus on developing therapeutics for immunomodulation, anti-aging (e.g., telomerase activation), cardiovascular protection, and the mitigation of diabetic complications. It is also studied for its potential in neuroprotection, anti-fatigue, and as an adjunct in cancer therapy for reducing chemotherapy side effects.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical in vitro and in vivo studies provide substantial evidence for the efficacy of Astragaloside III. Research demonstrates its ability to enhance immune response, improve cardiac function in models of heart failure, protect against diabetic nephropathy, and extend the replicative lifespan of cells (suggesting anti-aging potential). It shows significant anti-inflammatory and antioxidant effects in various disease models. While awaiting further human clinical trials, these robust preclinical data strongly support its therapeutic promise and justify its use in high-grade nutraceuticals and drug discovery.

4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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