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Chemicals
Teriparatide Acetate CAS NO.52232-67-4/99294-94-7
<p>Teriparatide Acetate is a potent osteoanabolic agent specifically designed for the treatment of severe osteoporosis in high-risk patients. As a recombinant fragment of human parathyroid hormone (PTH 1-34), it functions differently from traditional antiresorptive therapies by actively stimulating the formation of new bone tissue. It is indicated for postmenopausal women, men with primary or hypogonadal osteoporosi…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Teriparatide Acetate |
| CAS NO. | 52232-67-4/99294-94-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C181H291N55O51S2 |
| Molecular Weight | 4117.72 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water; reconstitutes in sterile buffer for injection |
| Endotoxin | < 5 EU/mg |
| Biological Activity | Stimulates osteoblast proliferation and bone formation; increases BMD |
| Storage Conditions | Store at 2–8°C; protect from light; do not freeze |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The therapeutic action of Teriparatide Acetate is mediated through its binding to the PTH1 receptor on osteoblasts, which activates signaling pathways that promote osteoblast differentiation and reduce apoptosis. When administered in an intermittent, once-daily regimen, it creates a net positive balance in bone remodeling by preferentially stimulating bone formation over resorption—a phenomenon known as the "anabolic window." This leads to significant improvements in bone microarchitecture, trabecular thickness, and overall bone strength, effectively reversing the structural deficits caused by severe osteoporosis.
2.PRODUCT INDICATIONS
Teriparatide Acetate is clinically approved for the management of osteoporosis in specific high-fracture-risk populations. Key indications include postmenopausal women with a history of osteoporotic fractures or very low bone mineral density (BMD), men with primary or hypogonadal osteoporosis, and patients who have developed osteoporosis secondary to long-term glucocorticoid therapy. It is particularly suited for individuals who have failed to respond adequately to conventional antiresorptive medications or who present with multiple risk factors for fragility fractures.
3.CLINICAL EFFICACY OF PRODUCT
Clinical trials and real-world studies have demonstrated that Teriparatide Acetate significantly increases lumbar spine BMD by approximately 9-10% over 18-21 months of treatment. More importantly, it reduces the risk of new vertebral fractures by about 65-70% and nonvertebral fragility fractures by approximately 50% compared to placebo. In head-to-head comparisons, it has shown superior fracture risk reduction versus risedronate in severe osteoporosis cases, making it a first-line anabolic option for patients requiring rapid bone quality restoration.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553
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Global Technology Co., Ltd.
