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Chemicals
ARA290 (Cibinetide) CAS NO.1208243-50-8
<p>ARA290 (Cibinetide) is a groundbreaking 11-amino acid synthetic peptide derived from the tissue-protective domain of erythropoietin (EPO), engineered to provide potent anti-inflammatory and neuroprotective benefits without stimulating red blood cell production. This non-erythropoietic peptide is a premier research tool for studying nerve regeneration and chronic inflammatory conditions, offering a unique mechanis…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | ARA290 (Cibinetide) |
| CAS NO. | 1208243-50-8 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C₅₁H₈₄N₁₆O₂₁ |
| Molecular Weight | 1257.31 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water; partially soluble in acidic aqueous solutions; insoluble in organic solvents like ethanol or DMSO at room temperature |
| Endotoxin | < 0.5 EU/mg (for pharmaceutical-grade material) |
| Biological Activity | Potent erythropoietin receptor agonist with selective activity in the brain, heart, and spinal cord; promotes neuroprotection, tissue repair, and anti-inflammatory responses without erythropoietic effects |
| Storage Conditions | Store at 2–8°C in a dry, dark place; protect from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Cibinetide selectively binds to and activates the Innate Repair Receptor (IRR), a heterodimeric complex of the EPO receptor and the β-common receptor (CD131). This targeted activation triggers downstream signaling pathways that inhibit apoptosis, reduce pro-inflammatory cytokine production (such as TNF-α and IL-6), and promote axonal sprouting, thereby facilitating tissue repair and nerve regeneration without affecting erythropoiesis or blood viscosity.
2.PRODUCT INDICATIONS
This product is indicated for preclinical research into small fiber neuropathy (SFN), diabetic peripheral neuropathy, and sarcoidosis-associated nerve damage, focusing on pain relief and nerve fiber density restoration. It is also utilized in studies of metabolic syndrome, ischemic tissue injury, and autoimmune conditions where tissue protection and anti-inflammatory modulation are key therapeutic goals.
3.CLINICAL EFFICACY OF PRODUCT
In Phase 2 clinical trials, ARA290 demonstrated significant efficacy in improving neuropathic pain scores and increasing corneal nerve fiber density in patients with sarcoidosis and diabetic neuropathy. Studies also report enhanced metabolic control and improved exercise capacity, with a favorable safety profile and no serious adverse events related to hematocrit elevation.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: ARA290 #Cibinetide #Neuropathy #NerveRegeneration #InnateRepairReceptor #AntiInflammatory #ResearchPeptide #TissueProtection
If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157
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Global Technology Co., Ltd.
