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Chemicals
Dihydrosanguinarine CAS NO.3606-45-9
<p>Dihydrosanguinarine is a natural benzophenanthridine alkaloid and a key metabolite of sanguinarine, primarily sourced from plants like <em>Macleaya cordata</em>and <em>Chelidonium majus</em>. Renowned for its multifaceted bioactivity, this high-purity compound is extensively utilized in pharmaceutical R&D, anticancer investigations, and antimicrobial studies. It serves as a critical research tool for scientists e…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Dihydrosanguinarine |
| CAS NO. | 3606-45-9 |
| Appearance | Off-white to light yellow powder |
| Molecular Formula | C₂₀H₁₅NO₄ |
| Molecular Weight | 333.34 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in dimethyl sulfoxide (DMSO), methanol; slightly soluble in ethanol; insoluble in water and non-polar solvents (e.g., hexane) |
| Endotoxin | ≤ 50 EU/mg (or as specified per batch; endotoxin testing optional for research-grade use) |
| Biological Activity | Anticancer, antibacterial, anti-inflammatory, anti-oxidant; induces apoptosis/ferroptosis, inhibits tumor cell proliferation, modulates signaling pathways (e.g., Ras/Raf/MEK/ERK, PI3K/Akt) |
| Storage Conditions | 2–8°C, protected from light and moisture; store in a tightly sealed container |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The compound exerts its effects through multiple interconnected pathways, including the inhibition of key signaling cascades such as Ras/Raf/MEK/ERK and PI3K/Akt, leading to cell cycle arrest at G0/G1 and G2/M phases. It modulates p53 protein dynamics and promotes the accumulation of reactive oxygen species (ROS), which triggers mitochondrial-mediated apoptosis and ferroptosis in malignant cells. Additionally, Dihydrosanguinarine demonstrates anti-inflammatory action by suppressing TNF and IL-17 pathways, while its antimicrobial properties involve disrupting fungal spore germination and microbial membrane integrity.
2.PRODUCT INDICATIONS
This product is specifically indicated for preclinical research in oncology, particularly for studying pancreatic, hepatic, and breast cancer models, as well as for investigating anti-inflammatory and immunomodulatory therapies. It is also applied in antimicrobial research against plant and animal pathogens, and in metabolic studies focusing on glucose uptake and tryptophan metabolism via the AhR pathway. The compound is essential for academic institutions, pharmaceutical companies, and biotech labs engaged in natural product drug discovery and mechanistic pharmacology.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical studies validate the efficacy of Dihydrosanguinarine, showing potent dose-dependent inhibition of cancer cell proliferation, migration, and invasion in models of pancreatic adenocarcinoma and hepatocellular carcinoma. Research confirms its ability to induce apoptosis and autophagy, enhance glucose uptake in adipocytes, and provide protective effects against LPS-induced liver inflammation. These robust pharmacological profiles support its investigational use as a promising lead compound for developing antitumor and anti-infective agents.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags:Dihydrosanguinarine, #DHSA, #NaturalAlkaloid, #AnticancerResearch, #Apoptosis, #PI3KInhibitor, #RasPathway, #MacleayaCordata, #Benzophenanthridine, #ResearchChemical
If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85244219157
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