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Chemicals
Acadesine CAS NO.2627-69-2
<p>Acadesine, widely known as AICAR, is a potent, cell-permeable nucleoside analog that serves as a direct and well-characterized pharmacological activator of AMP-activated protein kinase (AMPK), a central regulator of cellular energy metabolism. It is a cornerstone compound in metabolic research, exercise physiology, and drug discovery. This high-purity research chemical is essential for studying energy homeostasis…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Acadesine (AICAR) |
| CAS NO. | 2627-69-2 |
| Appearance | C9H14N4O5 |
| Molecular Formula | White to off-white crystalline powder |
| Molecular Weight | 258.23 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water and DMSO; slightly soluble in ethanol; insoluble in non-polar organic solvents |
| Endotoxin | ≤ 20 EU/mg (or as specified per batch; endotoxin testing recommended for biological applications) |
| Biological Activity | AMPK activator; promotes glucose uptake and fatty acid oxidation; enhances endurance and metabolic efficiency; studied for anti-diabetic, anti-obesity, and cardioprotective effects |
| Storage Conditions | 2–8°C, protected from light and moisture; store in tightly sealed container |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The primary mechanism of action of Acadesine involves its intracellular conversion to the monophosphorylated metabolite ZMP, which mimics AMP and allosterically activates AMPK. This activation shifts cellular metabolism towards catabolic processes, promoting glucose uptake, enhancing fatty acid oxidation, and stimulating mitochondrial biogenesis. By mimicking a state of low cellular energy, Acadesine effectively improves metabolic efficiency, reduces ectopic lipid accumulation, and enhances cellular stress resistance, underpinning its therapeutic potential for metabolic disorders.
2.PRODUCT INDICATIONS
This product is specifically indicated for advanced research applications in metabolism, endocrinology, and sports science, including studies on diabetes, obesity, non-alcoholic fatty liver disease, and exercise-induced adaptations. It is a critical tool for pharmaceutical R&D aimed at developing AMPK-targeted therapies for metabolic syndrome and ischemic conditions. Furthermore, Acadesine is utilized in preclinical models to investigate cardioprotection, muscle endurance, and the molecular basis of energy-sensing pathways, catering to the needs of academic, clinical, and industrial research laboratories.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical studies robustly support the efficacy of Acadesine, demonstrating its ability to improve glycemic control, reduce body weight, and enhance exercise endurance in rodent models of metabolic disease. Research indicates significant cardioprotective effects in models of myocardial ischemia-reperfusion injury. While human clinical trials are more limited, existing evidence points to its potential for modulating metabolism and protecting against ischemic damage, validating its role as a promising lead compound for the development of new therapeutics targeting metabolic and cardiovascular diseases.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Acadesine, #AICAR, #AMPKActivator, #MetabolicResearch, #DiabetesResearch, #ExerciseScience, #Cardioprotection, #ObesityResearch, #MitochondrialBiogenesis, #ResearchChemical
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