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Chemicals
Neferine CAS NO.2292-16-2
<p></p><div class="ybc-p"></div><p></p><div class="ybc-p">Neferine is a potent bisbenzylisoquinoline alkaloid naturally derived from the seed embryo of <em>Nelumbo nucifera</em>(lotus). Renowned for its broad-spectrum bioactivity, it serves as a high-purity reference standard and active ingredient for research in oncology, cardiovascular health, and metabolic disorders. This versatile compound is particularly valued…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Neferine |
| CAS NO. | 385769-84-6 |
| Appearance | Light yellow crystalline powder or amorphous solid (appearance may vary slightly depending on purification and solvent system) |
| Molecular Formula | C₃₈H₄₄N₂O₆ |
| Molecular Weight | 624.77 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in methanol, ethanol, DMSO, and chloroform; slightly soluble in water; insoluble in n-hexane |
| Endotoxin | < 0.5 EU/mg (for pharmaceutical-grade material; standard quality control parameter) |
| Biological Activity | Exhibits anti-inflammatory, neuroprotective, cardioprotective, and potential anti-cancer activities in preclinical models; modulates calcium channels, inhibits NF-κB pathway, and reduces oxidative stress |
| Storage Conditions | Store at 2–8°C in a dry, dark place; protect from light and moisture; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Neferine primarily exerts its effects by modulating critical cellular signaling pathways, including the inhibition of NF-κB and MAPK cascades to suppress pro-inflammatory cytokine production and oxidative stress. It induces apoptosis and autophagy in malignant cells through ROS generation and cell cycle arrest, while also demonstrating anti-fibrotic action by downregulating TGF-β1 and α-SMA expression in hepatic and pulmonary tissues.
2.PRODUCT INDICATIONS
This product is indicated for preclinical research applications focused on liver fibrosis reversal, cardiovascular protection (anti-arrhythmic and anti-thrombotic), and as an adjuvant in cancer therapy to overcome multidrug resistance. It is also utilized in neurological studies for its neuroprotective potential against seizures and cognitive decline, as well as in metabolic research for insulin sensitivity and anti-obesity investigations.
3.CLINICAL EFFICACY OF PRODUCT
In vivo and in vitro studies confirm that Neferine significantly attenuates CCl4-induced liver fibrosis by improving serum ALT/AST levels and reducing collagen deposition. It enhances the efficacy of chemotherapeutic agents like doxorubicin in resistant cancer cell lines and demonstrates potent cardioprotective effects by mitigating myocardial ischemia and arrhythmias in experimental models.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Neferine #LotusSeed #Bisbenzylisoquinoline #AntiFibrosis #Chemosensitizer #NFkB #ResearchChemical #NaturalAlkaloid
If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157
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Global Technology Co., Ltd.
