Columbin CAS NO.546-97-4

TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

Columbin exerts its primary effects through selective inhibition of the cyclooxygenase-2 (COX-2) enzyme, demonstrating a higher selectivity for COX-2 over COX-1, which is associated with a more favorable profile for reducing inflammation with potentially fewer side effects. Beyond prostaglandin suppression, its mechanism involves the modulation of the Wnt/β-catenin signaling pathway to promote osteogenic differentiation, as well as influencing cytochrome P450 (CYP450) enzyme activities and nuclear factor kappa B (NF-κB) related pathways to regulate glucose metabolism and inflammatory mediator production.

2.PRODUCT INDICATIONS

As a research-grade compound, Columbin is indicated for in vitro and in vivo studies focusing on inflammation, bone health, and metabolic diseases. Its primary research applications include investigating anti-arthritis and analgesic mechanisms, promoting osteogenesis and bone formation for osteoporosis research, and managing type 2 diabetes through hypoglycemic and lipid-lowering effects. It is also used in anti-infective research, such as anti-trypanosomal studies. The product is strictly intended for laboratory use by pharmaceutical R&D departments, academic researchers, and biotechnology companies.

3.CLINICAL EFFICACY OF PRODUCT

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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