(+)-Bicuculline CAS NO.485-49-4

TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

The compound functions by competitively binding to the GABA recognition site on the GABA_A receptor complex, thereby displacing the endogenous neurotransmitter GABA and preventing the opening of the associated chloride ion channel. This blockade of inhibitory postsynaptic potentials (IPSPs) leads to a net increase in neuronal excitability and depolarization. Additionally, it exhibits secondary activity as an inhibitor of small-conductance calcium-activated potassium (SK) channels, which further contributes to its ability to prolong action potentials and enhance synaptic responses, making it particularly useful for isolating glutamatergic currents in brain slice recordings.

2.PRODUCT INDICATIONS

This product is indicated for use in scientific investigations involving the modulation of inhibitory neurotransmission, including studies on epilepsy, anxiety, sleep-wake cycles, and cognitive function. It is specifically targeted for researchers in academic institutions and pharmaceutical R&D departments who require a reliable agent to induce seizure-like activity in animal models, to study the role of GABAergic inhibition in motor control, or to investigate the mechanisms of anesthetic reversal. Due to its potent convulsant nature, it is strictly contraindicated for human or veterinary therapeutic use and is intended solely for laboratory research purposes.

3.CLINICAL EFFICACY OF PRODUCT

While (+)-Bicuculline itself is not used clinically due to its severe convulsant toxicity, its efficacy as a research tool is well-established in validating the therapeutic potential of novel anticonvulsant drugs. In preclinical models, its application reliably induces synchronized neuronal discharges and seizures, allowing for the high-throughput screening of antiepileptic compounds. The product's consistent performance in suppressing GABAergic tone has made it a gold standard for confirming the on-target activity of GABAergic enhancers and for modeling hyperexcitability disorders in the central nervous system.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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